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自我管理项目与常规护理对患有多种疾病的社区老年人的影响:加拿大安大略省的一项实用随机对照试验

Self-management program versus usual care for community-dwelling older adults with multimorbidity: A pragmatic randomized controlled trial in Ontario, Canada.

作者信息

Fisher Kathryn, Markle-Reid Maureen, Ploeg Jenny, Bartholomew Amy, Griffith Lauren E, Gafni Amiram, Thabane Lehana, Yous Marie-Lee

机构信息

Aging, Community and Health Research Unit (ACHRU), McMaster University, Hamilton, Ontario, Canada.

School of Nursing, McMaster University, Hamilton, Ontario, Canada.

出版信息

J Comorb. 2020 Oct 16;10:2235042X20963390. doi: 10.1177/2235042X20963390. eCollection 2020 Jan-Dec.

Abstract

BACKGROUND

Multimorbidity, the co-existence of 2+ (or 3+) chronic diseases in an individual, is an increasingly common global phenomenon leading to reduced quality of life and functional status, and higher healthcare service use and mortality. There is an urgent need to develop and test new models of care that incorporate the components of multimorbidity interventions recommended by international organizations, including care coordination, interdisciplinary teams, and care plans developed with patients that are tailored to their needs and preferences.

PURPOSE

To determine the effectiveness of a 6-month, community-based, multimorbidity intervention compared to usual home care services for community-dwelling older adults (age 65+ years) with multimorbidity (3+ chronic conditions) that were newly referred to and receiving home care services.

METHODS

A pragmatic, parallel, two-arm randomized controlled trial evaluated the intervention, which included in-home visits by an interdisciplinary team, personal support worker visits, and monthly case conferences. The study took place in two sites in central Ontario, Canada. Eligible and consenting participants were randomly allocated to the intervention and control group using a 1:1 ratio. The participants, statistician/analyst, and research assistants collecting assessment data were blinded. The primary outcome was the Physical Component Summary (PCS) score of the 12-Item Short-Form health survey (SF-12). Secondary outcomes included the SF-12 Mental Component Summary (MCS) score, Center for Epidemiological Studies of Depression (CESD-10), Generalized Anxiety Disorder (GAD-7), Self-Efficacy for Managing Chronic Disease, and service use and costs. Analysis of covariance (ANCOVA) tested group differences using multiple imputation to address missing data, and non-parametric methods explored service use and cost differences.

RESULTS

59 older adults were randomized into the intervention (n = 30) and control (n = 29) groups. At baseline, groups were similar for the primary outcome and number of chronic conditions (mean of 8.6), but the intervention group had lower mental health status. The intervention was cost neutral and no significant group differences were observed for the primary outcome of PCS from SF-12 (mean difference: -4.94; 95% CI: -12.53 to 2.66; p = 0.20) or secondary outcomes.

CONCLUSION

We evaluated a 6-month, self-management intervention for older adults with multimorbidity. While the intervention was cost neutral in comparison to usual care, it was not found to improve the PCS from SF-12 or secondary health outcomes. Recruitment and retention challenges were significant obstacles limiting our ability to assess intervention effectiveness. Yet, the intervention was grounded in internationally-endorsed recommendations and implemented in a practice setting (home care) viewed as a key upstream resource fostering independence in older adults. These features collectively support the identification of ways to recruit/retain older adults and test alternative implementation strategies for interventions that are based on sound principles of multimorbidity management.

摘要

背景

多重疾病指个体同时患有两种及以上(或三种及以上)慢性病,这是一种在全球日益普遍的现象,会导致生活质量和功能状态下降,医疗服务使用增加以及死亡率上升。迫切需要开发并测试新的照护模式,这些模式应纳入国际组织推荐的多重疾病干预措施的组成部分,包括照护协调、跨学科团队以及与患者共同制定的、根据其需求和偏好量身定制的照护计划。

目的

确定一项为期6个月的基于社区的多重疾病干预措施与常规家庭护理服务相比,对新转诊并接受家庭护理服务的患有多重疾病(三种及以上慢性病)的社区居住老年人(65岁及以上)的有效性。

方法

一项实用、平行、双臂随机对照试验对该干预措施进行了评估,该干预措施包括跨学科团队的家访、个人支持工作者的家访以及每月的病例讨论会。该研究在加拿大安大略省中部的两个地点进行。符合条件并同意参与的参与者以1:1的比例随机分配到干预组和对照组。收集评估数据的参与者、统计学家/分析师和研究助理均处于盲态。主要结局是12项简短健康调查问卷(SF - 12)的身体成分总结(PCS)得分。次要结局包括SF - 12心理成分总结(MCS)得分、流行病学研究中心抑郁量表(CESD - 10)、广泛性焦虑障碍量表(GAD - 7)、慢性病自我管理效能感,以及服务使用情况和成本。协方差分析(ANCOVA)使用多重插补法处理缺失数据来检验组间差异,非参数方法则探讨服务使用和成本差异。

结果

59名老年人被随机分为干预组(n = 30)和对照组(n = 29)。在基线时,两组在主要结局和慢性病数量(平均8.6种)方面相似,但干预组的心理健康状况较低。该干预措施成本中性,在SF - 12的主要结局PCS(平均差异:-4.94;95%置信区间:-12.53至2.66;p = 0.20)或次要结局方面未观察到显著的组间差异。

结论

我们评估了一项针对患有多重疾病的老年人的为期6个月的自我管理干预措施。虽然与常规护理相比,该干预措施成本中性,但未发现其能改善SF - 12的PCS或次要健康结局。招募和留住参与者的挑战是限制我们评估干预效果能力的重大障碍。然而,该干预措施基于国际认可的建议,并在被视为促进老年人独立的关键上游资源的实践环境(家庭护理)中实施。这些特征共同支持确定招募/留住老年人的方法,并测试基于多重疾病管理合理原则的干预措施的替代实施策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a4e/7573753/1cf925a3bcba/10.1177_2235042X20963390-fig1.jpg

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