Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, United States.
Elife. 2020 Oct 29;9:e61675. doi: 10.7554/eLife.61675.
Vector-borne illnesses comprise a significant portion of human maladies, representing 17% of global infections. Transmission of vector-borne pathogens to mammals primarily occurs by hematophagous arthropods. It is speculated that blood may provide a unique environment that aids in the replication and pathogenesis of these microbes. Lipids and their derivatives are one component enriched in blood and are essential for microbial survival. For instance, the malarial parasite and the Lyme disease spirochete , among others, have been shown to scavenge and manipulate host lipids for structural support, metabolism, replication, immune evasion, and disease severity. In this , we will explore the importance of lipid hijacking for the growth and persistence of these microbes in both mammalian hosts and arthropod vectors.
虫媒病占人类疾病的很大一部分，占全球感染的 17%。虫媒病原体主要通过吸血节肢动物传播给哺乳动物。据推测，血液可能提供了一个独特的环境，有助于这些微生物的复制和发病机制。脂质及其衍生物是血液中丰富的一种成分，对微生物的生存至关重要。例如，疟原虫 和莱姆病螺旋体 等已经被证明可以掠夺和操纵宿主脂质以提供结构支持、代谢、复制、免疫逃避和疾病严重程度。在这篇综述中，我们将探讨脂质劫持对这些微生物在哺乳动物宿主和节肢动物载体中的生长和持续存在的重要性。
