HeRA：人类组织中增强子 RNA 的图谱。
HeRA: an atlas of enhancer RNAs across human tissues.
机构信息
Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Department of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
出版信息
Nucleic Acids Res. 2021 Jan 8;49(D1):D932-D938. doi: 10.1093/nar/gkaa940.
Enhancer RNA (eRNA) is a type of long non-coding RNA transcribed from DNA enhancer regions. Despite critical roles of eRNA in gene regulation, the expression landscape of eRNAs in normal human tissue remains unexplored. Using numerous samples from the Genotype-Tissue Expression project, we characterized 45 411 detectable eRNAs and identified tens of thousands of associations between eRNAs and traits, including gender, race, and age. We constructed a co-expression network to identify millions of putative eRNA regulators and target genes across different tissues. We further constructed a user-friendly data portal, Human enhancer RNA Atlas (HeRA, https://hanlab.uth.edu/HeRA/). In HeRA, users can search, browse, and download the eRNA expression profile, trait-related eRNAs, and eRNA co-expression network by searching the eRNA ID, gene symbol, and genomic region in one or multiple tissues. HeRA is the first data portal to characterize eRNAs from 9577 samples across 54 human tissues and facilitates functional and mechanistic investigations of eRNAs.
增强子 RNA（eRNA）是一类从 DNA 增强子区域转录而来的长非编码 RNA。尽管 eRNA 在基因调控中具有关键作用，但正常人体组织中 eRNA 的表达图谱仍未得到探索。我们使用来自 Genotype-Tissue Expression 项目的大量样本，对 45411 个可检测的 eRNA 进行了特征描述，并鉴定了 eRNA 与性别、种族和年龄等特征之间的数万个关联。我们构建了一个共表达网络，以识别不同组织中数百万个潜在的 eRNA 调节剂和靶基因。我们进一步构建了一个用户友好的数据门户，即人类增强子 RNA 图谱（HeRA，https://hanlab.uth.edu/HeRA/）。在 HeRA 中，用户可以通过在一个或多个组织中搜索 eRNA ID、基因符号和基因组区域，搜索、浏览和下载 eRNA 表达谱、与性状相关的 eRNA 和 eRNA 共表达网络。HeRA 是第一个对来自 54 个人体组织的 9577 个样本中的 eRNA 进行特征描述的数据集门户，它为 eRNA 的功能和机制研究提供了便利。
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