Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China.
Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China.
Life Sci. 2021 Jan 1;264:118669. doi: 10.1016/j.lfs.2020.118669. Epub 2020 Oct 26.
Hexokinase (HK) plays a key role in various biological processes such as glycolysis of tumor cells. However, there is still a lack of systematic understanding of the contribution of HK family genes in different types of cancer. In the present study, we systematically analyzed the molecular changes and clinical correlations of HK family genes in 33 types of cancer extracted from more than 10,000 subjects. As a result, there were extensive genetic changes in HK family genes and the expression levels of HK family were significantly correlated with the activity of cancer marker-related pathways. In addition, HK family genes may be useful in predicting prognosis and therapeutic efficacy. Moreover, HK1,HK2 and HK3 may become potential oncogenes across a variety of cancer types. Furthermore, the oncogenic functions of HK1 in bladder cancer have been confirmed in vitro. Collectively, our results provide valuable resources to guide the mechanism and therapeutic analysis concerning the role of HK family genes in cancer.
己糖激酶（HK）在多种生物过程中发挥着关键作用，如肿瘤细胞的糖酵解。然而，对于 HK 家族基因在不同类型癌症中的贡献，仍缺乏系统的认识。在本研究中，我们从 10000 多个样本中提取的 33 种癌症中，系统分析了 HK 家族基因的分子变化和临床相关性。结果表明，HK 家族基因存在广泛的遗传变化，并且 HK 家族的表达水平与癌症标志物相关通路的活性显著相关。此外，HK 家族基因可能有助于预测预后和治疗效果。此外，HK1、HK2 和 HK3 可能成为多种癌症类型的潜在致癌基因。此外，HK1 在膀胱癌中的致癌作用已在体外得到证实。综上所述，我们的研究结果为指导 HK 家族基因在癌症中的作用的机制和治疗分析提供了有价值的资源。
