Department of Bioproducts and Biosystems, Aalto University, Kemistintie 1, Espoo, 02150, Finland.
Adv Healthc Mater. 2021 Jan;10(1):e2001162. doi: 10.1002/adhm.202001162. Epub 2020 Oct 29.
The strategy of combining biomolecules and synthetic components to develop biohybrids is becoming increasingly popular for preparing highly customized and biocompatible functional materials. Carbon nanotubes (CNTs) benefit from bioconjugation, allowing their excellent properties to be applied to biomedical applications. This study reviews the state-of-the-art research in biomolecule-CNT conjugates and discusses strategies for their self-assembly into hierarchical structures. The review focuses on various highly ordered structures and the interesting properties resulting from the structural order. Hence, CNTs conjugated with the most relevant biomolecules, such as nucleic acids, peptides, proteins, saccharides, and lipids are discussed. The resulting well-defined composites allow the nanoscale properties of the CNTs to be exploited at the micro- and macroscale, with potential applications in tissue engineering, sensors, and wearable electronics. This review presents the underlying chemistry behind the CNT-based biohybrid materials and discusses the future directions of the field.
将生物分子和合成成分结合起来开发生物杂种的策略，对于制备高度定制和生物相容的功能材料越来越受欢迎。碳纳米管（CNT）得益于生物共轭，使其优异的性能能够应用于生物医学应用。本研究综述了生物分子-CNT 缀合物的最新研究进展，并讨论了它们自组装成分级结构的策略。本综述重点介绍了各种高度有序的结构以及结构有序带来的有趣性质。因此，讨论了与最相关的生物分子（如核酸、肽、蛋白质、糖和脂质）共轭的 CNT。所得的定义明确的复合材料允许在微尺度和宏观尺度上利用 CNT 的纳米级性质，在组织工程、传感器和可穿戴电子领域具有潜在应用。本综述介绍了基于 CNT 的生物杂种材料背后的基础化学，并讨论了该领域的未来方向。
