Masmejan Sophie, Musso Didier, Vouga Manon, Pomar Leo, Dashraath Pradip, Stojanov Milos, Panchaud Alice, Baud David
Maternofetal and Obstetrics Research Unit, Department "Woman-Mother-Child", University Hospital, 1011 Lausanne, Switzerland.
Laboratoire Eurofins Labazur Guyane, 97300 Cayenne, French Guiana.
Pathogens. 2020 Oct 28;9(11):898. doi: 10.3390/pathogens9110898.
Zika virus (ZIKV), a neurotropic single-stranded RNA flavivirus, remains an important cause of congenital infection, fetal microcephaly, and Guillain-Barré syndrome in populations where ZIKV has adapted to a nexus involving the mosquitoes and humans. To date, outbreaks of ZIKV have occurred in Africa, Southeast Asia, the Pacific islands, the Americas, and the Caribbean. Emerging evidence, however, suggests that the virus also has the potential to cause infections in Europe, where autochtonous transmission of the virus has been identified. This review focuses on evolving ZIKV epidemiology, modes of transmission and host-virus interactions. The clinical manifestations, diagnostic issues relating to cross-reactivity to the dengue flavivirus and concerns surrounding ZIKV infection in pregnancy are discussed. In the last section, current challenges in treatment and prevention are outlined.
寨卡病毒（ZIKV）是一种嗜神经性单链RNA黄病毒，在寨卡病毒已适应蚊子和人类相互关联环境的人群中，它仍然是先天性感染、胎儿小头畸形和吉兰-巴雷综合征的重要病因。迄今为止，寨卡病毒已在非洲、东南亚、太平洋岛屿、美洲和加勒比地区爆发。然而，新出现的证据表明，该病毒在欧洲也有引发感染的可能，欧洲已发现该病毒的本土传播。本综述重点关注寨卡病毒不断演变的流行病学、传播方式以及宿主与病毒的相互作用。文中还讨论了其临床表现、与登革热黄病毒交叉反应相关的诊断问题以及孕期寨卡病毒感染的相关问题。在最后一部分，概述了当前治疗和预防方面的挑战。
