Mouillet-Richard Sophie, Laurent-Puig Pierre
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France.
Institut du Cancer Paris CARPEM, APHP, Department of Biology, Hôpital Européen Georges Pompidou, F-75015 Paris, France.
Cancers (Basel). 2020 Oct 28;12(11):3160. doi: 10.3390/cancers12113160.
Recent advance in the characterization of the heterogeneity of colorectal cancer has led to the definition of a consensus molecular classification within four CMS subgroups, each associated with specific molecular and clinical features. Investigating the signalling pathways that drive colorectal cancer progression in relation to the CMS classification may help design therapeutic strategies tailored for each CMS subtype. The two main effectors of the Hippo pathway YAP and its paralogue TAZ have been intensively scrutinized for their contribution to colon carcinogenesis. Here, we review the knowledge of YAP/TAZ implication in colorectal cancer from the perspective of the CMS framework. We identify gaps in our current understanding and delineate research avenues for future work.
结直肠癌异质性特征的最新进展已促成在四个共识分子亚组内定义了一种共识分子分类，每个亚组都与特定的分子和临床特征相关。研究与共识分子亚组分类相关的驱动结直肠癌进展的信号通路，可能有助于设计针对每种共识分子亚组亚型的治疗策略。Hippo信号通路的两个主要效应因子YAP及其旁系同源物TAZ对结肠癌发生的作用已得到深入研究。在此，我们从共识分子亚组框架的角度综述YAP/TAZ在结直肠癌中的作用相关知识。我们确定了当前理解中的差距，并勾勒了未来工作的研究方向。
