Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Department of Medicine, Dunedin School of Medicine, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Acta Diabetol. 2021 May;58(5):539-547. doi: 10.1007/s00592-020-01623-4. Epub 2020 Oct 31.
The do-it-yourself artificial pancreas system (DIYAPS) is a patient-driven initiative with the potential to revolutionise diabetes management, automating insulin delivery with existing pumps and CGM combined with open-source algorithms. Given the considerable interest in this topic within the diabetes community, we have conducted a systematic review of DIYAPS efficacy, safety, and user experience. Following recognised procedures and reporting standards, we identified 10 eligible publications of 730 participants within the peer-reviewed literature. Overall, studies reported improvements in time in range, HbA1c (glycated haemoglobin), reduced hypoglycaemia, and improved quality of life with DIYAPS use. While results were positive, the identified studies were small, and the majority were observational and at high risk of bias. Further research including well-designed randomised trials comparing DIYAPS with appropriate comparators is recommended.
DIYAPS 是一种由患者驱动的自主人工胰腺系统，具有改变糖尿病管理的潜力，它通过将现有的胰岛素泵和 CGM 与开源算法相结合来实现胰岛素的自动输送。鉴于糖尿病患者对该主题的浓厚兴趣，我们对 DIYAPS 的疗效、安全性和用户体验进行了系统评价。我们遵循公认的程序和报告标准，在同行评议文献中确定了 10 篇符合条件的出版物，涉及 730 名参与者。总的来说，研究报告显示 DIYAPS 可改善时间范围内的血糖控制、糖化血红蛋白（HbA1c）水平、减少低血糖事件，并提高生活质量。虽然结果是积极的，但确定的研究规模较小，大多数是观察性研究且存在较高的偏倚风险。建议开展进一步的研究，包括使用适当对照进行设计良好的随机试验，以比较 DIYAPS 的效果。
