恶性疟原虫S抗原基因中重复序列数量、序列及阅读框的变化。

Saint R B, Coppel R L, Cowman A F, Brown G V, Shi P T, Barzaga N, Kemp D J, Anders R F

Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

Mol Cell Biol. 1987 Aug;7(8):2968-73. doi: 10.1128/mcb.7.8.2968-2973.1987.

The S antigens from different isolates of Plasmodium falciparum exhibit extensive size, charge, and serological diversity. We show here that the S-antigen genes behave as multiple alleles of a single locus. The size heterogeneity results from different numbers, lengths, and/or sequences of tandem repeat units encoded within the S-antigen genes. Two genes studied here encode antigenically different S antigens but nevertheless have closely related tandem repeat sequences. We show that antigenic differences can arise because repeats are translated in different reading frames.

来自恶性疟原虫不同分离株的S抗原在大小、电荷和血清学方面表现出广泛的多样性。我们在此表明，S抗原基因表现为单个基因座的多个等位基因。大小异质性源于S抗原基因内编码的串联重复单元的数量、长度和/或序列不同。此处研究的两个基因编码抗原性不同的S抗原，但仍具有密切相关的串联重复序列。我们表明，抗原性差异可能是因为重复序列在不同的阅读框中翻译。