潜在序列周期性的检测。
Detection of latent sequence periodicities.
作者信息
Pizzi E, Liuni S, Frontali C
机构信息
Laboratorio di Biologia Cellulare, Istituto Superiore di Sanità, Rome, Italy.
出版信息
Nucleic Acids Res. 1990 Jul 11;18(13):3745-52. doi: 10.1093/nar/18.13.3745.
Abstract
A method is proposed for the automatic detection of serial periodicities in a linear sequence. Its application to DNA subtelomeric sequences from two lower eukaryotes, P.falciparum and S.cerevisiae, reveals ordered patterns organised in hierarchical periodicities, not easily recognizable by other methods. The possible implications concerning the evolution of tandemly repetitive arrays are discussed in light of a model which involves, as successive steps, random repeat modification, the fusion of differently modified repeat versions into longer units, and the amplification of (and/or homogenization to) the more recent repeat units.
摘要
本文提出了一种用于自动检测线性序列中连续周期性的方法。将其应用于两种低等真核生物恶性疟原虫和酿酒酵母的DNA亚端粒序列，揭示了以分层周期性组织的有序模式，这是其他方法难以识别的。根据一个模型讨论了串联重复阵列进化的可能影响，该模型涉及作为连续步骤的随机重复修饰、将不同修饰的重复版本融合成长度更长的单元，以及较新重复单元的扩增（和/或同质化）。
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