Pothmann R
Kinderklinik, Wuppertal.
Monatsschr Kinderheilkd. 1987 Sep;135(9):646-9.
30 children between 7 and 17 years suffering from at least 2 attacks/month of common or classical migraine since more than 1 year were studied. After clinical exclusion of symptomatic headache 4 weeks were documented by means of a migraine diary. Prophylaxis with Calcium entry blocker Flunarizine (Sibelium) or Thromboxane A inhibitor Acetylsalicylic acid (ASS) was carried out in a double blind design for 3 months. Medication was given as one dosage in the evening: 2-5 mg/kg KG ASS or 5-10 mg Flunarizine. Documented attack frequency and duration were controlled at monthly physical examinations. Final results showed no differences in significant reduction of attack frequency or symptoms between both different therapeutic principals. 72.4% (ASS 73.3%; Flunarizine 71.4%) of patients were attack-free or had at least a 50% reduction. Migraine frequency of initially 7-8 was reduced to 1-2 attacks/month. Duration remained constant in both groups (1-3 h). Side effects were slight body weight gain or abdominal pain after intake, prophylaxis had not to be interrupted therefore. Longtime prognosis is not yet possible because the time of observation is too short so far.
Both substances are definitely useful and have few side effects in childhood migraine. If the response to one is insufficient the other substance should be tried.
对30名7至17岁、患普通型或典型偏头痛且每月至少发作2次、病程超过1年的儿童进行了研究。在临床排除症状性头痛后，通过偏头痛日记记录4周情况。采用双盲设计，用钙通道阻滞剂氟桂利嗪（西比灵）或血栓素A抑制剂乙酰水杨酸（阿司匹林）进行3个月的预防性治疗。药物于每晚单次给药：阿司匹林2 - 5mg/kg体重或氟桂利嗪5 - 10mg。在每月体检时记录发作频率和持续时间。最终结果显示，两种不同治疗原则在显著降低发作频率或症状方面无差异。72.4%（阿司匹林组73.3%；氟桂利嗪组71.4%）的患者无发作或发作次数至少减少50%。最初每月发作7 - 8次的偏头痛频率降至每月1 - 2次。两组发作持续时间均保持不变（1 - 3小时）。副作用为服药后轻微体重增加或腹痛，因此无需中断预防性治疗。由于观察时间至今过短，尚无法得出长期预后情况。
两种药物对儿童偏头痛肯定有效且副作用少。若对一种药物反应不足，应尝试另一种药物。
