Fonatsch C, Gradl G
Institut für Humangenetik, Medizinische Universität zu Lübeck.
Onkologie. 1987 Aug;10(4):206-16. doi: 10.1159/000216408.
Chromosomal findings in malignant lymphomas are correlated to the histopathology and the immunologic phenotype of lymphoma subgroups. The prognostic significance of a cytogenetic analysis and its value for therapy planning are discussed. With respect to tumorigenesis it is emphasized that a number of proto-oncogenes and genes for cell differentiation, such as immunoglobulin and T-cell receptor genes, have been localized at sites of recurring chromosomal rearrangements. One chapter deals with cytogenetic data in correlation to findings of DNA recombination studies in Hodgkin's disease.
恶性淋巴瘤的染色体研究结果与淋巴瘤亚组的组织病理学和免疫表型相关。本文讨论了细胞遗传学分析的预后意义及其在治疗方案制定中的价值。关于肿瘤发生，着重指出一些原癌基因和细胞分化基因，如免疫球蛋白和T细胞受体基因，已定位在染色体反复重排的部位。其中一章论述了与霍奇金病DNA重组研究结果相关的细胞遗传学数据。
