Lee Do-Youn, Nam Seung-Min
Department of Physical Therapy, Daegu University, Gyeongsan, Korea.
Osong Public Health Res Perspect. 2020 Feb;11(1):27-33. doi: 10.24171/j.phrp.2020.11.1.05.
This study was performed to test the association between lung function and type 2 diabetes mellitus (T2DM) in Korean patients.
Data from the 6 Korea National Health and Nutrition Examination Survey (2013 to 2015) was used in this study. There were 3,466 individuals aged between 40 and 80 years, with T2DM, who had a smoking and alcohol status listed, and blood analysis (including blood pressure), were included in this study. Lung function, measured by spirometer ventilatory dysfunction was categorized into 3 patterns: normal, restrictive ventilatory dysfunction, and obstructive ventilatory dysfunction (OVD).
Based on multivariate logistic regression analysis, individuals with restrictive ventilatory dysfunction had an increased odds ratio (OR 1.615, 95% CI 1.137-2.294) for T2DM compared with individuals with normal ventilatory function, whereas OVD had no increase in the odds ratio (OR 1.169, 95 % CI 0.857-1.594). Model 1, which adjusted for age and gender, showed that the probability of having restrictive disorder was 1.559 times (95% CI 1.617-2.082) higher for prediabetes patients, and 2.320 times (95% CI 1.611-3.343) higher for T2DM patients, compared to normal individuals. For Model 4, which was fully adjusted for variables, the probability of having a restrictive disorder was 1.837 times higher for T2DM patients (95% CI 1.260-2.679).
Restrictive ventilatory dysfunction, but not OVD, was associated independently with T2DM.
本研究旨在检测韩国患者肺功能与2型糖尿病（T2DM）之间的关联。
本研究使用了韩国国家健康与营养检查调查（2013年至2015年）的6次数据。本研究纳入了3466名年龄在40至80岁之间、患有T2DM、有吸烟和饮酒状况记录且进行了血液分析（包括血压）的个体。通过肺活量计测量的肺功能通气功能障碍分为3种类型：正常、限制性通气功能障碍和阻塞性通气功能障碍（OVD）。
基于多因素逻辑回归分析，与通气功能正常的个体相比，患有限制性通气功能障碍的个体患T2DM的比值比（OR）增加（OR 1.615，95%可信区间[CI] 1.137 - 2.294），而OVD的比值比没有增加（OR 1.169，95% CI 0.857 - 1.594）。调整了年龄和性别的模型1显示，与正常个体相比，糖尿病前期患者患限制性疾病的概率高1.559倍（95% CI 1.617 - 2.082），T2DM患者高2.320倍（95% CI 1.611 - 3.343）。对于对变量进行了完全调整的模型4，T2DM患者患限制性疾病的概率高1.837倍（9
限制性通气功能障碍而非OVD与T2DM独立相关。 5% CI 1.260 - 2.679）。
