Anti- activity of acomplex mixture of HP7 including the extract of and .

The effect of standard therapeutic strategies on infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm the enhanced effect of HP7, which has been reported to exert antibacterial and gastric mucosal protective effects, in combination with var. acuta ()and () extracts. extract and extract were found to inhibit the growth of in a concentration-dependent manner, and the combination of HP7 and extract and extract effectively inhibited from attaching to AGS a gastric epithelial cells. Moreover, HP7 complex mixture containing and extracts has been shown to inhibit virulence genes such as AlpA, CagA, FlaA and UreA. When -infected mice were administered a complex mixture of HP7 containing and extract, the infection rate of was significantly reduced. In addition, the HP7 complex mixture significantly reduced serum IL-8 levels and stomach inflammation in infected mice. These results suggest that a complex mixture of HP7 containing and extracts may be an alternative to treating diseases caused by infection.