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以及HP7对……的抑制作用 。（你提供的原文信息不完整，翻译可能不太准确，建议补充完整内容以便更精准翻译）

and inhibition of by HP7.

作者信息

Hong Seong-Soo, Lee Hyun-A, Kim Joo Yun, Jeong Ji-Woong, Shim Jae-Jung, Lee Jung Lyoul, Sim Jae-Hun, Chung Yungho, Kim Okjin

机构信息

Division of Gastroenterology, Vievisnamuh Hospital, Seoul, Korea.

Center for Animal Resource Development, Wonkwang University, Iksan, Korea.

出版信息

Lab Anim Res. 2018 Dec;34(4):216-222. doi: 10.5625/lar.2018.34.4.216. Epub 2018 Dec 31.

DOI:10.5625/lar.2018.34.4.216
PMID:30671108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6333598/
Abstract

The efficacy of standard therapeutic strategies for () infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investigated the capacity of () HP7, isolated from kimchi, to inhibit growth. The effects of HP7 on adhesion and -induced inflammation were examined in AGS human gastric adenocarcinoma epithelial cells and a mouse model of SS1 infection. HP7 reduced adhesion to AGS cells and suppressed the inflammatory response in infected cells by downregulating interleukin-8. colonization in the stomach of C57BL/6 mice was demonstrated by rapid urease test, and results showed significant decrease in mice post-treated with HP7. Additionally, HP7 decreased gastric inflammation and epithelial lesions in the stomach of -infected mice. These results demonstrate that HP7 treatment can inhibit growth and is thus a promising treatment for patients with gastric symptoms such as gastritis that are caused by infection.

摘要

由于耐药菌株的出现，针对（）感染的标准治疗策略的疗效正随着时间的推移而下降。作为一种替代方法，本研究调查了从泡菜中分离出的（）HP7抑制（）生长的能力。在AGS人胃腺癌细胞和（）SS1感染的小鼠模型中，检测了HP7对（）黏附及（）诱导的炎症的影响。HP7减少了（）对AGS细胞的黏附，并通过下调白细胞介素-8抑制了感染细胞中的炎症反应。通过快速尿素酶试验证实了（）在C57BL/6小鼠胃中的定植，结果显示用HP7处理后的小鼠中（）显著减少。此外，HP7减轻了（）感染小鼠胃中的胃部炎症和上皮损伤。这些结果表明，HP7治疗可以抑制（）生长，因此对于由（）感染引起的胃炎等胃部症状的患者是一种有前景的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e349/6333598/1a9199466489/lar-34-216-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e349/6333598/e1ed4b40c321/lar-34-216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e349/6333598/9d6b25bc60b1/lar-34-216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e349/6333598/a59ee8d85159/lar-34-216-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e349/6333598/1a9199466489/lar-34-216-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e349/6333598/e1ed4b40c321/lar-34-216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e349/6333598/9d6b25bc60b1/lar-34-216-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e349/6333598/a59ee8d85159/lar-34-216-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e349/6333598/1a9199466489/lar-34-216-g004.jpg

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