Whelan Adrian M, Johansen Kirsten L, McCulloch Charles E, Adelmann Dieter, Niemann Claus U, Roll Garrett R, Siyahian Salpi, Grimes Barbara, Ku Elaine
Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA.
Division of Nephrology, Department of Medicine, Hennepin County Medical Center, Minneapolis, MN.
Transplant Direct. 2020 Sep 17;6(10):e602. doi: 10.1097/TXD.0000000000001048. eCollection 2020 Oct.
Rates of kidney transplantation vary substantially across dialysis facilities in the United States. Whether distance between the dialysis facility and transplant center associates with variations in transplantation rates has not been examined.
We performed a retrospective study of adults treated with dialysis between 2005 and 2015, according to the US Renal Data System. We examined the association between distance from dialysis facility to transplant center and time to kidney transplantation (primary outcome) and waitlist registration (secondary outcome) using Fine-Gray models. We also performed sensitivity analyses using the distance from each patient's dialysis facility to the nearest transplant center as the predictor so that patients who were never registered on the waitlist (and therefore would not have a transplant center) could be included.
In total, 178 885 waitlisted patients were included for our primary analysis. As distance between dialysis facility and transplant center increased, lower hazard of transplantation (subhazard ratio [HR], 0.92; 95% confidence interval [CI], 0.91-0.94, if distance was 10 to <50 miles; sub-HR, 0.90; 95% CI, 0.88-0.92, if distance ≥50 miles compared with <10 miles) was noted. We also found a weak association between longer distance and hazard of waitlist registration (sub-HR, 0.96; 95% CI, 0.94-0.97, if distance was ≥50 miles versus <10 miles). Findings were similar in sensitivity analyses using distance between dialysis facility and the nearest transplant center (N = 1 149 721).
Patients receiving dialysis in facilities located further away from transplant centers have lower hazard of kidney transplantation. Developing strategies to address barriers to transplantation in patients receiving dialysis at facilities located far away from a transplant center may help improve disparities in transplantation rates.
美国各透析机构的肾移植率差异很大。透析机构与移植中心之间的距离是否与移植率的差异相关尚未得到研究。
根据美国肾脏数据系统,我们对2005年至2015年间接受透析治疗的成年人进行了一项回顾性研究。我们使用Fine-Gray模型研究了透析机构到移植中心的距离与肾移植时间(主要结局)和等待名单登记(次要结局)之间的关联。我们还进行了敏感性分析,使用每个患者透析机构到最近移植中心的距离作为预测因素,以便纳入从未在等待名单上登记(因此没有移植中心)的患者。
我们的主要分析共纳入了178885名列入等待名单的患者。随着透析机构与移植中心之间距离的增加,移植风险降低(亚风险比[HR]为0.92;95%置信区间[CI]为0.91-0.94,若距离为10至<50英里;亚HR为0.90;95%CI为0.88-0.92,若距离≥50英里与<10英里相比)。我们还发现距离较长与等待名单登记风险之间存在微弱关联(亚HR为0.96;95%CI为0.94-0.97,若距离≥50英里与<10英里相比)。在使用透析机构与最近移植中心之间距离的敏感性分析中(N = 1149721),结果相似。
在距离移植中心较远的机构接受透析的患者肾移植风险较低。制定策略以解决在远离移植中心的机构接受透析的患者的移植障碍,可能有助于改善移植率的差异。