Department of Food Science and Nutrition, The University of Suwon, Hwasung, Korea.
Department of Food and Nutrition, Chonnam National University, Gwangju, Korea.
J Med Food. 2020 Dec;23(12):1296-1302. doi: 10.1089/jmf.2020.4779. Epub 2020 Nov 2.
Cranberry powder (CR) is reported to be effective against lower urinary tract symptoms (LUTS) and recurrent urinary tract infections. Benign prostatic hyperplasia (BPH) in men older than 50 years is a common cause of LUTS. Here, we attempted to evaluate if CR is also effective for treating BPH using a BPH-induced rat model, which was orally administered CR. Male Sprague-Dawley rats weighing 200-250 g were randomly divided into the following six groups ( = 9): noncastration group; castration group; BPH group; BPH and cranberry for 8-week (CR8W) group; BPH and cranberry for 4-week (CR4W) group; and BPH and saw palmetto group (saw palmetto). Compared with the BPH group, the CR8W group showed a significant decrease in prostate weight (by 33%), dihydrotestosterone (DHT) levels (by 18% in serum and 28% in prostate), 5-alpha reductase levels (18% reduction of type 1 and 35% of type 2), and histological changes. These results indicate that CR could attenuate BPH by inhibiting 5-alpha reductase and by reducing other biomarkers such as prostate weight and DHT levels. Thus, CR may be an effective candidate for the development of a functional food for BPH treatment. IACUC (USW-IACUC-R-2015-004).
蔓越莓粉（CR）被报道对下尿路症状（LUTS）和复发性尿路感染有效。50 岁以上男性的良性前列腺增生（BPH）是 LUTS 的常见原因。在这里，我们尝试使用 BPH 诱导的大鼠模型评估 CR 是否也可有效治疗 BPH，该模型经口给予 CR。200-250g 的雄性 Sprague-Dawley 大鼠被随机分为以下六组（n=9）：非去势组；去势组；BPH 组；BPH 和蔓越莓 8 周（CR8W）组；BPH 和蔓越莓 4 周（CR4W）组；和锯棕榈组（锯棕榈）。与 BPH 组相比，CR8W 组的前列腺重量（降低 33%）、二氢睾酮（DHT）水平（血清中降低 18%，前列腺中降低 28%）、5-α 还原酶水平（1 型降低 18%，2 型降低 35%）和组织学变化均显著降低。这些结果表明，CR 通过抑制 5-α 还原酶和降低前列腺重量和 DHT 水平等其他生物标志物，可减轻 BPH。因此，CR 可能是治疗 BPH 的功能性食品的有效候选物。IACUC（USW-IACUC-R-2015-004）。
