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新冠病毒与维生素D:疾病死亡率与阳光照射呈负相关。

Covid-19 and vit-d: Disease mortality negatively correlates with sunlight exposure.

作者信息

Lansiaux Édouard, Pébaÿ Philippe P, Picard Jean-Laurent, Forget Joachim

机构信息

Henry Warembourg School of Medicine, Lille University, 59000, Lille, France.

NexGen Analytics, Sheridan, WY, 82801, U.S.A..

出版信息

Spat Spatiotemporal Epidemiol. 2020 Nov;35:100362. doi: 10.1016/j.sste.2020.100362. Epub 2020 Jul 23.

Abstract

The novel COVID-19 disease is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a new virus of the coronavirus family, SARS-CoV-2. Alike with other coronaviruses, some studies show a COVID-19 neurotropism, inducing de-myelination lesions as encountered in Guillain-Barré syndrome. In particular, an Italian report concluded that there is a significant vitamin D deficiency in COVID-19 infected patients. In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. For instance in continental metropolitan France, average annual sunlight hours are significantly (for a p-value of 1.532 × 10) correlated to the COVID-19 mortality rate, with a Pearson coefficient of -0.636. This correlation hints at a protective effect of sunlight exposure against COVID-19 mortality. This paper is proposed to foster academic discussion and its hypotheses and conclusions need to be confirmed by further research.

摘要

新型冠状病毒肺炎是一种传染性急性呼吸道传染病,其病原体已被证实是冠状病毒家族的一种新型病毒,即严重急性呼吸综合征冠状病毒2(SARS-CoV-2)。与其他冠状病毒一样,一些研究表明新型冠状病毒具有嗜神经性,可引发如吉兰-巴雷综合征中出现的脱髓鞘病变。特别是,一份意大利报告得出结论,新型冠状病毒感染患者存在明显的维生素D缺乏。在本研究中,我们对公共卫生数据以及气象数据应用了皮尔逊相关性检验,以评估新型冠状病毒肺炎死亡率与阳光照射之间的线性关系。例如,在法国大陆大都市地区,年平均日照时数与新型冠状病毒肺炎死亡率显著相关(p值为1.532×10),皮尔逊系数为-0.636。这种相关性暗示了阳光照射对新型冠状病毒肺炎死亡率具有保护作用。本文旨在促进学术讨论,其假设和结论需要进一步研究来证实。

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