Buller Maggie C, Johnson Lynelle R, Outerbridge Catherine A, Vernau William, White Stephen D
William R. Pritchard Veterinary Medical Teaching Hospital, University of California School of Veterinary Medicine, Davis, California, USA.
Department of Medicine and Epidemiology, University of California School of Veterinary Medicine, Davis, California, USA.
J Vet Intern Med. 2020 Nov;34(6):2671-2676. doi: 10.1111/jvim.15951. Epub 2020 Nov 3.
Eosinophilic airway disease in cats is sometimes described as allergic in origin, but controversy exists in the documentation of allergy in cats and the utility of allergy testing for respiratory tract diseases.
To examine serum immunoglobulin E (IgE) response to aeroallergens in cats with airway eosinophilia.
Fifteen cats with idiopathic eosinophilic airway inflammation and 9 control cats.
Prospective, case-control study. Surplus serum from cats with airway eosinophilia documented by bronchoscopic bronchoalveolar lavage was submitted for IgE measurement using ELISA polyclonal antibody methodology. Responses for regional allergens (fungal organisms, weeds, grasses, trees, mites, insects) were assessed. Results were reported as ELISA absorbance units with scores 0 to 79 considered negative, scores between 80 and 300 considered intermediate, and scores >300 considered positive.
Cats with airway eosinophilia had significantly more positive serum IgE responses (25/720) than did healthy controls (5/432, P = .02); however, the number of cats with positive IgE responses (5/15) did not differ from controls (1/9, P = .35). The allergen that most commonly resulted in positive serum IgE response in cats with airway eosinophilia was dust mite (n = 4) followed by 2 types of storage mites (n = 3 each). No control cat tested positive for these allergens.
Serum IgE production against aeroallergens was found in some cats with eosinophilic airway inflammation, but the number of affected cats with positive results did not differ from controls. Further investigation in cats with eosinophilic, mixed, and neutrophilic airway disease in comparison to control cats is warranted.
猫嗜酸性气道疾病有时被描述为起源于过敏，但猫过敏的记录以及呼吸道疾病过敏检测的实用性存在争议。
研究气道嗜酸性粒细胞增多的猫对气传变应原的血清免疫球蛋白E（IgE）反应。
15只特发性嗜酸性气道炎症猫和9只对照猫。
前瞻性病例对照研究。通过支气管镜支气管肺泡灌洗记录气道嗜酸性粒细胞增多的猫的剩余血清，采用ELISA多克隆抗体方法进行IgE测量。评估对区域变应原（真菌、杂草、草、树、螨、昆虫）的反应。结果以ELISA吸光度单位报告，0至79分被视为阴性，80至300分被视为中等，大于300分被视为阳性。
气道嗜酸性粒细胞增多的猫血清IgE阳性反应（25/720）显著多于健康对照猫（5/432，P = 0.02）；然而，IgE阳性反应的猫的数量（5/15）与对照猫（1/9）没有差异（P = 0.35）。在气道嗜酸性粒细胞增多的猫中，最常导致血清IgE阳性反应的变应原是尘螨（n = 4），其次是2种仓储螨（各n = 3）。没有对照猫对这些变应原检测呈阳性。
在一些嗜酸性气道炎症的猫中发现了针对气传变应原的血清IgE产生，但阳性结果的患病猫数量与对照猫没有差异。有必要对嗜酸性、混合性和中性粒细胞性气道疾病的猫与对照猫进行进一步研究。
