Moriello Karen A, Stepien Rebecca L, Henik Rosemary A, Wenholz Lisa J
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive West, Madison, WI 53706, USA.
Vet Dermatol. 2007 Apr;18(2):94-100. doi: 10.1111/j.1365-3164.2007.00573.x.
The purpose of this study was to determine the prevalence of positive allergen reactions in cats with small-airway disease (i.e. 'feline asthma', 'feline allergic bronchitis', 'feline bronchial disease'). Intradermal skin tests (IDT) and serum immunoglobulin E (IgE) tests were performed in 10 cats with idiopathic small-airway disease and in 10 normal cats without a history of respiratory disease. None of the cats had a history of skin disease or clinical signs of skin disease at the time of testing. Significantly more individual positive allergen reactions were found on serum IgE tests than on IDT in both groups of cats. Affected cats had significantly more individual positive allergen reactions on both tests than unaffected cats. Both IDT and serum IgE tests resulted in more individual positive allergen reactions to weeds, trees, grasses, and/or moulds in affected cats than in normal cats. Significantly more positive allergen reactions to house dust mites were found in affected compared to non-affected cats by IDT but not by serum IgE testing. One unexpected obstacle to inclusion of more affected cats in the study was the concurrent presence or history of suspect or known allergic skin disease. Concurrent allergic skin disease has not been reported in association with small-airway disease in cats. The increased prevalence of individual positive allergen reactions in affected cats may be due to increased immunological reactivity in these cats. Further studies are needed to answer this question and to determine what role, if any, aeroallergens have in the pathogenesis of this complex feline disease.
本研究的目的是确定患有小气道疾病（即“猫哮喘”、“猫过敏性支气管炎”、“猫支气管疾病”）的猫中过敏原阳性反应的患病率。对10只患有特发性小气道疾病的猫和10只无呼吸道疾病病史的正常猫进行了皮内皮肤试验（IDT）和血清免疫球蛋白E（IgE）检测。在检测时，所有猫均无皮肤病病史或皮肤病临床症状。在两组猫中，血清IgE检测发现的个体阳性过敏原反应均显著多于IDT检测。患病猫在两项检测中出现的个体阳性过敏原反应均显著多于未患病猫。与正常猫相比，患病猫的IDT和血清IgE检测对杂草、树木、草和/或霉菌产生的个体阳性过敏原反应更多。通过IDT检测发现，与未患病猫相比，患病猫对屋尘螨的阳性过敏原反应显著更多，但血清IgE检测未发现此差异。本研究纳入更多患病猫的一个意外障碍是同时存在或有可疑或已知过敏性皮肤病的病史。尚未有关于猫的小气道疾病与并发过敏性皮肤病相关的报道。患病猫个体阳性过敏原反应患病率的增加可能是由于这些猫免疫反应性增强。需要进一步研究来回答这个问题，并确定气传过敏原在这种复杂的猫科疾病发病机制中是否起作用（若有作用，则作用是什么）。
