Akdeniz Şifa Hospital, Antalya, Turkey.
Dermatology and Venereology Department, Akdeniz University School of Medicine, Antalya, Turkey.
BMC Dermatol. 2020 Nov 3;20(1):14. doi: 10.1186/s12895-020-00111-0.
There are reports that acrochordon (skin tag), the most common fibroepithelial tumor of the skin, may be associated with metabolic syndrome components, particularly insulin metabolism disorders. However, to the best of our knowledge, there is no study examining its association with insulin resistance and tissue levels of insulin-like growth factor 1 receptor (IGF-1R) and insulin-like growth factor 2 receptor (IGF-2R).
Thirty patients with at least one acrochordon in their body who had no known history of diabetes mellitus and a control group comprised 30 individuals who had no acrochordon or no known history of diabetes mellitus were included. The tissue expression of IGF-1R and IGF-2R were investigated via immunohistochemical assessment in both groups.
In the group with acrochordon, IGF-1R and IGF-2R expression was found to be significantly higher compared to the control group (p < 0,01). Using logistic regression analysis, an increase in serum insulin, serum IGF-1 and HOMA-IR levels was found to be associated with the expression levels of IGF-1R and IGF-2R.
These findings support the view that insulin metabolism disorders should be evaluated in patients with acrochordon. Our study indicates that IGF receptors may have an effect on acrochordon pathogenesis and that acrochordon etiology and related conditions can be clarified by detection of parameters that influence receptor levels.
有报道称，皮赘（皮肤软纤维瘤）是最常见的皮肤纤维上皮瘤，可能与代谢综合征成分有关，特别是胰岛素代谢紊乱。然而，据我们所知，尚无研究探讨其与胰岛素抵抗以及组织中胰岛素样生长因子 1 受体（IGF-1R）和胰岛素样生长因子 2 受体（IGF-2R）水平的关系。
纳入 30 例体表至少有 1 个皮赘且无已知糖尿病病史的患者作为皮赘组，以及 30 例体表无皮赘且无已知糖尿病病史的个体作为对照组。采用免疫组织化学评估方法检测两组的 IGF-1R 和 IGF-2R 组织表达情况。
皮赘组的 IGF-1R 和 IGF-2R 表达明显高于对照组（p<0.01）。通过逻辑回归分析发现，血清胰岛素、血清 IGF-1 和 HOMA-IR 水平升高与 IGF-1R 和 IGF-2R 的表达水平相关。
这些发现支持胰岛素代谢紊乱应在皮赘患者中进行评估的观点。本研究表明，IGF 受体可能对皮赘发病机制有影响，通过检测影响受体水平的参数可以阐明皮赘的病因及相关情况。
