Department of Internal Medicine, Akdeniz University, Antalya, Turkey.
Clin Exp Med. 2010 Sep;10(3):193-7. doi: 10.1007/s10238-009-0086-5. Epub 2009 Dec 24.
Although skin tags are associated with diabetes mellitus, insulin resistance, hypertension, obesity, atherogenic lipid profile, no data in the literature show that the presence of skin tags is associated with serum high-sensitive C-reactive protein, uric acid, free fatty acid and leptin level. The purpose of this study was to evaluate the frequency of hypertension, dyslipidemia, insulin resistance and obesity in patients with skin tags and to compare patients with skin tags and normal healthy subjects for insulin resistance, serum lipids, insulin, glucose, leptin, high-sensitive C-reactive protein, free fatty acid levels. We evaluated 113 patients with skin tags and 31 healthy subjects. The two groups were compared with respect to BMI, lipid profile, blood pressure, insulin resistance, serum lipids, insulin, glucose, leptin, high-sensitive C-reactive protein, free fatty acid and homeostatic model assessment of insulin resistance (HOMA-IR). Total 53.9 and 33.6% of patients with skin tags were overweight and obese, respectively. The frequency of hypertension 30.1%, dyslipidemia 59.3% and insulin resistance 21.2% were detected. HOMA-IR (P < 0.001) and serum glucose (P < 0.001), insulin (P = 0.002), high-sensitive C-reactive protein (P = 0.001), uric acid (P = 0.001), free fatty acid (P = 0.002), HbA1c (P < 0.001), total cholesterol (P = 0.018), LDL-cholesterol (P = 0.023), and triglyceride levels (P = 0.001) were higher in patients with skin tags than control group. Overweight and/or obesity, dyslipidemia, hypertension, insulin resistance and elevated high-sensitive C-reactive protein are seen in patients with skin tags. Skin tags may be a marker of increased risk of atherosclerosis and cardiovascular disease.
虽然皮肤标签与糖尿病、胰岛素抵抗、高血压、肥胖、致动脉粥样硬化脂质谱有关，但文献中没有数据表明皮肤标签的存在与血清高敏 C 反应蛋白、尿酸、游离脂肪酸和瘦素水平有关。本研究旨在评估皮肤标签患者中高血压、血脂异常、胰岛素抵抗和肥胖的频率，并比较皮肤标签患者和正常健康受试者的胰岛素抵抗、血清脂质、胰岛素、血糖、瘦素、高敏 C 反应蛋白、游离脂肪酸水平。我们评估了 113 名皮肤标签患者和 31 名健康受试者。两组在 BMI、血脂谱、血压、胰岛素抵抗、血清脂质、胰岛素、血糖、瘦素、高敏 C 反应蛋白、游离脂肪酸和稳态模型评估的胰岛素抵抗 (HOMA-IR) 方面进行了比较。分别有 53.9%和 33.6%的皮肤标签患者超重和肥胖。高血压的发生率为 30.1%，血脂异常为 59.3%，胰岛素抵抗为 21.2%。HOMA-IR（P<0.001）和血清葡萄糖（P<0.001）、胰岛素（P=0.002）、高敏 C 反应蛋白（P=0.001）、尿酸（P=0.001）、游离脂肪酸（P=0.002）、HbA1c（P<0.001）、总胆固醇（P=0.018）、LDL-胆固醇（P=0.023）和甘油三酯水平（P=0.001）在皮肤标签患者中均高于对照组。超重和/或肥胖、血脂异常、高血压、胰岛素抵抗和高敏 C 反应蛋白升高见于皮肤标签患者。皮肤标签可能是动脉粥样硬化和心血管疾病风险增加的标志物。
