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在阿片类药物减停中促进以患者为中心:去实施科学蓝图

Promoting Patient-Centeredness in Opioid Deprescribing: a Blueprint for De-implementation Science.

作者信息

Kertesz Stefan G, McCullough Megan B, Darnall Beth D, Varley Allyson L

机构信息

Birmingham VA Medical Center, Birmingham, AL, USA.

Division of Preventive Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.

出版信息

J Gen Intern Med. 2020 Dec;35(Suppl 3):972-977. doi: 10.1007/s11606-020-06254-7. Epub 2020 Nov 3.

Abstract

A downward trend in opioid prescribing between 2011 and 2018 has brought per-capita opioid prescriptions below the levels of 2006, the earliest year for which the Centers for Disease Control and Prevention has published data. That trend has affected roughly ten million patients who previously received long-term opioid therapy. Any effort to reduce or replace a prior health practice is termed de-implementation. We suggest that the evaluation of opioid prescribing de-implementation has been misdirected, within US policy and health research, resulting in detrimental impacts on patients, their families and clinicians. Policymakers and implementation scientists can address these deficiencies in how we study and how we perform opioid de-implementation by applying an implementation science framework: the Consolidated Framework for Implementation Research. The Consolidated Framework lays out relevant domains of activity (internal, external, etc.) that influence implementation processes and outcomes. It can deepen our understanding of how policies are chosen, communicated, and carried out. Policymakers and researchers who embrace this framework will need a better approach to measuring success and failure in health care where both pain and opioids are concerned. This would involve shifting from a reductive focus on opioid prescription counts toward measures that are more effective, holistic, and patient-centered.

摘要

2011年至2018年间阿片类药物处方量呈下降趋势,使得人均阿片类药物处方量低于2006年的水平,2006年是美国疾病控制与预防中心公布数据的最早年份。这一趋势影响了约1000万此前接受长期阿片类药物治疗的患者。任何减少或取代先前医疗行为的努力都被称为“去实施”。我们认为,在美国政策和卫生研究中,对阿片类药物处方“去实施”的评估方向有误,给患者、其家人及临床医生带来了不利影响。政策制定者和实施科学家可以通过应用一种实施科学框架——《实施研究综合框架》来解决我们在研究阿片类药物“去实施”以及实际进行阿片类药物“去实施”过程中的这些不足。《实施研究综合框架》列出了影响实施实施过程和结果的相关活动领域(内部、外部等)。它可以加深我们对政策如何选择、传达和执行的理解。接受这一框架的政策制定者和研究人员将需要一种更好的方法来衡量在涉及疼痛和阿片类药物的医疗保健中的成败。这将涉及从单纯关注阿片类药物处方数量转向采用更有效、更全面且以患者为中心的衡量标准。

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