Payen D, Ecoffey C, Carli P, Dubousset A M
Department of Anesthesiology of Lariboisière University Hospital, Paris, France.
Anesthesiology. 1987 Nov;67(5):681-5. doi: 10.1097/00000542-198711000-00011.
Hemodynamic effects of caudal bupivacaine anesthesia were studied in eight infants 6.5 +/- 0.5 months old (mean +/- SD), weighing 7.4 +/- 4.4 kg anesthetized with halothane 0.2% end-tidal and 60% nitrous oxide. Heart rate and systolic, diastolic, and mean arterial pressure remained unchanged. Cardiac index and stroke index assessed by pulsed Doppler and total vascular resistances were not altered by the caudal block. However, after caudal anesthesia, the authors observed a significant decrease (P less than 0.05) in brachial blood flow assessed by pulsed Doppler (from 49.0 +/- 28.3 to 31.7 +/- 24.6 ml-1.min) and a significant increase (P less than 0.05) in brachial vascular resistance (from 2.9 +/- 1.7 to 5.5 +/- 1.0 mmHg.min.ml-1). Blood flow and vascular resistance in both the femoral and carotid arteries did not change. This study suggests that, in supine position, caudal anesthesia in infants induces a blood pooling in the denervated lower extremities and a reflex vasoconstriction in innervated areas which maintains cardiac output. We conclude that volume loading is not necessary in normovolemic infants after caudal anesthesia with cutaneous analgesia below T5.
在8名6.5±0.5个月大(平均±标准差)、体重7.4±4.4千克的婴儿中,研究了骶管布比卡因麻醉的血流动力学效应。这些婴儿采用0.2%呼气末氟烷和60%氧化亚氮麻醉。心率以及收缩压、舒张压和平均动脉压均保持不变。通过脉冲多普勒评估的心脏指数和每搏指数以及总血管阻力并未因骶管阻滞而改变。然而,在骶管麻醉后,作者观察到通过脉冲多普勒评估的肱动脉血流显著减少(P<0.05)(从49.0±28.3降至31.7±24.6毫升·分钟⁻¹),并且肱动脉血管阻力显著增加(P<0.05)(从2.9±1.7升至5.5±1.0毫米汞柱·分钟·毫升⁻¹)。股动脉和颈动脉的血流及血管阻力均未改变。本研究表明,在仰卧位时,婴儿骶管麻醉会导致去神经支配的下肢血液淤积,并在神经支配区域引起反射性血管收缩,从而维持心输出量。我们得出结论,对于T5以下皮肤镇痛的骶管麻醉后血容量正常的婴儿,无需进行容量负荷。