Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University Fuzhou, Fujian, 350108, China.
Chem Soc Rev. 2020 Dec 21;49(24):9197-9219. doi: 10.1039/d0cs00604a. Epub 2020 Nov 4.
Halodifluoromethyl and trifluoromethyl-containing compounds are widely employed in organic chemistry, pharmaceuticals and materials science. Therefore, their applications and transformations have received significant attention during the past few decades. The single, double, triple and quadruple cleavage of halodifluoromethyl compounds and various deconstructive modes of trifluoromethyl-containing compounds could generate a variety of synthons to prepare more valuable products. Herein, we summarize the most significant achievements in this field with an intriguing focus on results from the last decade.
含卤二氟甲基和三氟甲基的化合物在有机化学、药物和材料科学中得到了广泛的应用。因此，在过去几十年中，它们的应用和转化受到了极大的关注。卤二氟甲基化合物的单、双、三、四重键断裂和含三氟甲基化合物的各种解构模式可以生成各种合成子来制备更有价值的产物。在此，我们总结了这一领域的最重要成果，特别关注过去十年的研究成果。
