Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran.
Complement Ther Clin Pract. 2020 Nov;41:101256. doi: 10.1016/j.ctcp.2020.101256. Epub 2020 Oct 29.
The present study was aimed to evaluate the nano-curcumin supplementation on Th1/Th17 balance by assessment of gene expression and serum level of interferon gamma (IFN-γ) and interleukin-17 (IL-17) in migraine patients.
Forty participants with episodic migraine were randomly allocated to receive 80 mg nano-curcumin (n = 20) or placebo (n = 20) in a randomized double-blind clinical trial for two months. The expression of IFN-γ and IL-17 from peripheral blood mononuclear cells and IFN-γ and IL-17 serum levels were measured, using a real-time PCR and ELISA methods, respectively.
Compared to placebo group, two month nano-curcumin supplementation led to a significant reduction in serum levels and expression of IL-17 mRNA (P = 0.006 & 0.04, respectively), while there was no statistical difference regarding serum levels and expression of IFN-γ mRNA.
Nano-curcumin supplementation in migraine patients led to a significant reduction in gene expression and plasma levels of IL-17 compared to control group.
本研究旨在通过评估干扰素 γ（IFN-γ）和白细胞介素-17（IL-17）的基因表达和血清水平，评估纳米姜黄素补充对偏头痛患者 Th1/Th17 平衡的影响。
40 名发作性偏头痛患者被随机分为两组，分别接受 80mg 纳米姜黄素（n=20）或安慰剂（n=20），进行为期两个月的随机双盲临床试验。采用实时 PCR 和 ELISA 法分别检测外周血单个核细胞中 IFN-γ 和 IL-17 的表达以及 IFN-γ 和 IL-17 的血清水平。
与安慰剂组相比，两个月的纳米姜黄素补充治疗可显著降低血清 IL-17 mRNA 的水平和表达（P=0.006 和 0.04），而 IFN-γ mRNA 的血清水平和表达则无统计学差异。
与对照组相比，偏头痛患者补充纳米姜黄素可显著降低 IL-17 的基因表达和血浆水平。
