Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Poursina Street, Tehran, Iran.
Amir Alam Hospital Complexes, Tehran University of Medical Sciences, Sa'adi Street, Tehran, Iran.
BMC Res Notes. 2022 May 23;15(1):189. doi: 10.1186/s13104-022-06074-4.
The present study aimed to investigate the effects of nano-curcumin supplementation on adipokines levels and clinical signs in obese and overweight patients with migraine.
Forty-four patients with episodic migraine participated in this clinical trial and were divided into two groups nano-curcumin (80 mg/day) and the control group over 2-month period. At the baseline and the end of the research, the serum levels of MCP-1, Resistin, and Visfatin were measured using the ELISA method. In addition, the headache attack frequencies, severity, and duration of pain were recorded. The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%). In the case of resistin and visfatin, nano-curcumin supplementation exerted no statistically significant changes in serum levels (P > 0.05). Nano-curcumin also significantly reduced the attack frequencies, severity, and duration of headaches (P < 0.05). These findings indicate that targeting curcumin can be a promising approach to migraine management. However, further comprehensive human trials are needed to confirm these findings.
This study was registered in the Iranian Registry of Clinical Trials (IRCT) with ID number: IRCT20160626028637N2 on the date 2020-07-10.
本研究旨在探讨纳米姜黄素补充对肥胖和超重偏头痛患者脂联素水平及临床症状的影响。
44 名发作性偏头痛患者参与了这项临床试验，并分为纳米姜黄素（80mg/天）组和对照组，为期 2 个月。在基线和研究结束时，采用 ELISA 法测量血清 MCP-1、抵抗素和 Visfatin 水平。此外，还记录了头痛发作频率、严重程度和疼痛持续时间。本研究结果表明，纳米姜黄素可显著降低纳米姜黄素补充组血清 MCP-1 水平（P=0.015，效应大小=13.4%）。在抵抗素和 Visfatin 方面，纳米姜黄素补充对血清水平无统计学显著变化（P>0.05）。纳米姜黄素还显著降低了头痛发作频率、严重程度和持续时间（P<0.05）。这些发现表明，靶向姜黄素可能是治疗偏头痛的一种有前途的方法。然而，需要进一步的全面人体试验来证实这些发现。
本研究于 2020 年 7 月 10 日在伊朗临床试验注册中心（IRCT）注册，注册号为 IRCT20160626028637N2。
