Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States
Division of Hematology, Oncology, and Stem Cell Transplant, Rush University Medical Center, Chicago, IL, United States.
BMJ Case Rep. 2020 Nov 3;13(11):e235308. doi: 10.1136/bcr-2020-235308.
Gestational breast cancer (GBC) is the most common form of invasive cancer in pregnancy and has unique challenges in both staging and treatment given the dual goal of appropriate cancer management and minimising the risk of fetal toxicity. A 38-year-old woman with no significant medical history and 21 weeks pregnant presented with a palpable right breast mass. She was diagnosed with human epidermal growth factor receptor 2-positive infiltrating ductal carcinoma with advanced disease. The patient underwent treatment; however, unfortunately, she passed away after developing devastating distant disease recurrence.We highlight both the challenges and current guidelines for management of GBC. Our goal is to discuss the current limitations of GBC management and the necessity of further investigation for safe novel imaging and treatment modalities for pregnant women. It is crucial to increase awareness across multiple subspecialities, as a multidisciplinary team is necessary for proper treatment of GBC.
妊娠性乳腺癌（GBC）是妊娠期间最常见的侵袭性癌症形式，由于双重目标是适当的癌症管理和最小化胎儿毒性的风险，因此在分期和治疗方面都具有独特的挑战。一位 38 岁的妇女，没有显著的病史，怀孕 21 周，出现可触及的右侧乳腺肿块。她被诊断为人类表皮生长因子受体 2 阳性浸润性导管癌，疾病已进展。患者接受了治疗；然而，不幸的是，她在发生毁灭性的远处疾病复发后去世了。我们强调了 GBC 管理的挑战和当前指南。我们的目标是讨论 GBC 管理的当前局限性以及为孕妇安全的新型成像和治疗方式进行进一步研究的必要性。提高多个亚专业的认识至关重要，因为多学科团队是 GBC 适当治疗的必要条件。
