Consejo Nacional de Ciencia y Tecnología, Mexico, Mexico.
Universidad de Santander, Bucaramanga, Colombia.
Sci Rep. 2020 Nov 4;10(1):19017. doi: 10.1038/s41598-020-75891-z.
The variability in the host immune response directed against dengue virus (DENV) has demonstrated the need to understand the immune response associated with protection in incident infection. The objective was to estimate the association between serostatus and the risk of incident DENV infection. We used a prospective study from 2014 to 2016 in the localities of Axochiapan and Tepalcingo, Morelos, Mexico. We recruited 966 participants, of which, according to their infection history registered were categorized in four groups. To accomplish the objectives of this study, we selected to 400 participants older than 5 years of age were followed for 2.5 years. Blood samples were taken every 6 months to measure serological status and infection by ELISA. In individuals with at least two previous infections the risk of new infection was lower compared to a seronegative group (hazard ratio adjusted 0.49, 95% CI 0.24-0.98), adjusted for age and locality. Therefore, individuals who have been exposed two times or more to a DENV infection have a lower risk of re-infection, thus showing the role of cross-immunity and its association with protection.
宿主针对登革病毒（DENV）的免疫反应存在变异性，这表明需要了解与初次感染相关的免疫反应。本研究旨在评估血清阳性状态与新发 DENV 感染风险之间的关联。我们采用了 2014 年至 2016 年在墨西哥莫雷洛斯州的阿科奇潘和特帕琴戈进行的前瞻性研究。共招募了 966 名参与者，根据其既往感染史，将他们分为四个组别。为了完成本研究的目标，我们选择了 400 名年龄大于 5 岁的参与者进行了 2.5 年的随访。每 6 个月采集一次血样，以通过 ELISA 检测血清学状态和感染情况。与血清阴性组相比，至少有两次既往感染的个体新发感染的风险较低（调整后的危险比为 0.49，95%置信区间为 0.24-0.98），调整因素为年龄和地点。因此，两次或更多次接触 DENV 感染的个体再次感染的风险较低，这表明交叉免疫的作用及其与保护的相关性。
