Amaya-Larios Irma Y, Rojas-Russell Mario, López-Cervantes Malaquias, Castro-Porras Lilia, Castro-Borbonio Ma Victoria, Sarti Elsa, Puentes-Rosas Esteban, Tirado-Gómez Laura L, Olaíz-Fernandez Gustavo, Ramos-Castañeda José
Instituto Nacional de Salud Publica. Centro de Investigaciones sobre Enfermedades Infecciosas, Cuernavaca, Morelos. CP, Mexico.
Universidad Nacional Autonoma de Mexico, Centro de Investigaciones en Politica, Poblacion y Salud, Mexico City, CP, Mexico.
Trans R Soc Trop Med Hyg. 2018 May 1;112(5):223-229. doi: 10.1093/trstmh/try046.
Dengue is the most important arboviral disease in the world. Seroprevalence has been proposed as a marker of endemicity, however, studies are scarce.
We conducted a cross-sectional, stratified cluster, random sample study to measure the seroprevalence of antibodies to dengue virus (DENV) in Mexico. The target population was school children ages 6-17 y from 22 endemic states in Mexico, clustered in four regions: Pacific, South-Central, Southeast and Low.
A total of 2134 subjects provided blood samples for immunoglobulin G antibody detection in serum by enzyme-linked immunosorbent assay. Overall, the seroprevalence of antibodies against DENV was 33.5% (95% confidence interval [CI] 27.5 to 40.1). The Southeast had the highest regional seroprevalence, reaching 70.9% (95% CI 60.3 to 79.7). Seroprevalence was higher in older children in the Southeast region: 62.1% (95% CI 46.9 to 75.2) in children 6-8 y and 82.6% (95% CI 73.8 to 88.9) in 13-17 years old (y). However, this was not consistent in all regions. Seroprevalence was associated with dengue incidence.
DENV seroprevalence in Mexico was found to be heterogeneous at the country, regional and state levels. Seroprevalence was linked to long-term exposure and did not adequately reflect recent patterns of transmission, suggesting that utilization of a single epidemiological indicator to define endemic regions should be avoided.
登革热是全球最重要的虫媒病毒病。血清流行率已被提议作为地方性流行的一个指标，然而相关研究较少。
我们开展了一项横断面、分层整群随机抽样研究，以测量墨西哥登革热病毒（DENV）抗体的血清流行率。目标人群是来自墨西哥22个地方性流行州的6至17岁学童，分为四个地区：太平洋地区、中南部地区、东南部地区和低地地区。
共有2134名受试者提供血样，通过酶联免疫吸附测定法检测血清中的免疫球蛋白G抗体。总体而言，抗DENV抗体的血清流行率为33.5%（95%置信区间[CI]为27.5至40.1）。东南部地区的区域血清流行率最高，达到70.9%（95%CI为60.3至79.7）。东南部地区年龄较大儿童的血清流行率更高：6至8岁儿童为62.1%（95%CI为46.9至75.2），13至17岁儿童为82.6%（95%CI为73.8至88.9）。然而，并非所有地区都是如此。血清流行率与登革热发病率相关。
墨西哥的DENV血清流行率在国家、区域和州层面存在异质性。血清流行率与长期暴露有关，不能充分反映近期的传播模式，这表明应避免使用单一的流行病学指标来定义地方性流行区域。
