儿童残余胆固醇与腹部肥胖的关系：一项横断面研究。
The relationship of remnant cholesterol and abdominal obesity in children: A cross-sectional study.
作者信息
Tong Jishuang, Li Xinggui, Liang Xiaoyue, Tang Fang, Ren Yanling, Hao Guang, Peng Xin, Luo Sunqing, Feng Ye, Huang Daochao, Zhao Li, Liang Xiaohua
机构信息
Clinical Epidemiology and Biostatistics Department, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Key Laboratory of Pediatrics in Chongqing, China International Science and Technology Cooperation Center of Child Development and Critical Disorders, Chongqing, China.
Shimian People's Hospital, Ya'an, China.
出版信息
Front Cardiovasc Med. 2022 Jul 27;9:929560. doi: 10.3389/fcvm.2022.929560. eCollection 2022.
BACKGROUND
Previous studies found that remnant cholesterol (RC) is a risk factor for cardiovascular diseases and childhood obesity is associated with cardiometabolic diseases. This study aimed to explore the relationship between RC and abdominal obesity in children.
METHODS
A total of 5,959 children, aged 6-12 years old, were selected from a cross-sectional study in urban-rural areas of Chongqing, China. RC was calculated by total cholesterol (TC)-high-density lipoprotein (HDL-C) cholesterol-low-density lipoprotein (LDL-C) cholesterol and was divided into four groups by quartiles (Q1-Q4).
RESULTS
Compared to children with the lowest RC (Q1), children with higher RC had significantly higher odds of abdominal obesity (Q2: OR = 1.450, 95% CI: 1.131-1.859, < 0.05; Q3: OR = 2.127, 95% CI: 1.632-2.772, < 0.001; Q4: OR = 2.386, 95% CI: 1.819-3.130, < 0.001). In the stratified analyses by urban-rural areas, the odds ratios were greater in rural areas (Q2: OR = 2.228, 95% CI: 1.572-3.160, < 0.001; Q3: OR = 3.668, 95% CI: 2.191-6.140, < 0.001; Q4: OR = 6.490, 95% CI: 2.271-18.551, < 0.001) than in urban areas (Q2: OR = 1.644, 95% CI: 1.192-2.266, < 0.05; Q3: OR = 2.266, 95% CI: 1.667-3.082, < 0.001; Q4: OR = 2.711, 95% CI: 2.005-3.665, < 0.001).
CONCLUSIONS
Our study found that RC was positively correlated with abdominal obesity in children, and this association was higher for children living in rural areas.
背景
既往研究发现，残余胆固醇（RC）是心血管疾病的危险因素，儿童肥胖与心脏代谢疾病相关。本研究旨在探讨儿童RC与腹型肥胖之间的关系。
方法
从中国重庆城乡地区的一项横断面研究中选取了5959名6至12岁的儿童。RC通过总胆固醇（TC）-高密度脂蛋白（HDL-C）胆固醇-低密度脂蛋白（LDL-C）胆固醇计算得出，并按四分位数（Q1-Q4）分为四组。
结果
与RC最低的儿童（Q1）相比，RC较高的儿童腹型肥胖的几率显著更高（Q2：OR = 1.450，95%CI：1.131-1.859，P<0.05；Q3：OR = 2.127，95%CI：1.632-2.772，P<0.001；Q4：OR = 2.386，95%CI：1.819-3.130，P<0.001）。在按城乡地区分层分析中，农村地区的比值比高于城市地区（Q2：OR = 2.228，95%CI：1.572-3.160，P<0.001；Q3：OR = 3.668，95%CI：2.191-6.140，P<0.001；Q4：OR = 6.490，95%CI：2.271-18.551，P<0.001）（城市地区：Q2：OR = 1.644，95%CI：1.192-2.266，P<0.05；Q3：OR = 2.266，95%CI：1.667-3.082，P<0.001；Q4：OR = 2.711，95%CI：2.005-3.665，P<0.001）。
结论
我们的研究发现，儿童RC与腹型肥胖呈正相关，且这种关联在农村地区儿童中更高。
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