基于聚集诱导发光基团的比率型荧光探针用于检测活细胞中的 HClO。
A ratiometric fluorescent probe based on AIEgen for detecting HClO in living cells.
机构信息
Department of Urology, First Affiliated Hospital of Soochow University, 188 Shizi RD, Suzhou 215006, China.
出版信息
Chem Commun (Camb). 2020 Dec 4;56(93):14613-14616. doi: 10.1039/d0cc06582j. Epub 2020 Nov 5.
PMID:33150877
Abstract
A new ratiometric fluorescent probe, namely TPE-RNS, has been developed for detecting intracellular HClO/ClO in living cells and discriminating cancer cells from normal cells. Based on the ratiometric fluorescence properties conferred by the AIE and DTBET effects, this probe has excellent sensitivity and specificity for the HCIO response.
摘要
一种新的比率荧光探针，即 TPE-RNS，已被开发用于检测活细胞内的 HClO/ClO，并区分癌细胞和正常细胞。基于 AIE 和 DTBET 效应赋予的比率荧光特性，该探针对 HCIO 的响应具有优异的灵敏度和特异性。
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