College of Chinese Medicine Materials, Jilin Agricultural University, Changchun, China.
Changchun Institute of Technology School of Medicine, Changchun, China.
J Food Biochem. 2021 Jan;45(1):e13556. doi: 10.1111/jfbc.13556. Epub 2020 Nov 5.
The cellular defense pathway plays a key role in maintaining the homeostasis, tissues and organisms. Nuclear factor E2-related factor 2 (Nrf2), as a key cell signaling pathway, plays an important role in encoding detoxification enzymes and other stress response mediators. Recent studies have shown that it is closely related to the prevention and treatment of acute kidney injury (AKI). Therefore, this article reviews the protective effects of Nrf2-related signaling pathways on acute kidney injury, and summarizes the strategies of natural pharmaceutical ingredients such as flavonoids, alkaloids, terpenes, phenylpropionic acid, polyphenols, and polysaccharides to prevent and treat acute kidney injury. It is of great significance to further study the relationship between Nrf2 regulated signal pathway and kidney disease and the development of new medicines for acute kidney injury treatment. It can also provide new ideas and treatment strategies for clinical treatment of acute kidney injury. PRACTICAL APPLICATIONS: This article reviewed the mechanisms by which the active ingredients of natural medicines slow down acute kidney injury through the Nrf2 pathway. It will help us to understand the regulatory role of the Nrf2 pathway in AKI more comprehensively, and provide a theoretical basis for further exploring the mechanism of more natural drugs to reduce acute kidney injury.
细胞防御途径在维持体内平衡、组织和生物体方面起着关键作用。核因子 E2 相关因子 2（Nrf2）作为关键的细胞信号通路，在编码解毒酶和其他应激反应介质方面发挥着重要作用。最近的研究表明，它与急性肾损伤（AKI）的预防和治疗密切相关。因此，本文综述了 Nrf2 相关信号通路对急性肾损伤的保护作用，并总结了黄酮类、生物碱类、萜类、苯丙酸类、多酚类和多糖类等天然药物成分预防和治疗急性肾损伤的策略。这对于进一步研究 Nrf2 调节信号通路与肾脏疾病的关系以及开发治疗急性肾损伤的新药具有重要意义。它也为急性肾损伤的临床治疗提供了新的思路和治疗策略。
本文综述了天然药物活性成分通过 Nrf2 途径减缓急性肾损伤的作用机制。这将帮助我们更全面地了解 Nrf2 通路在 AKI 中的调节作用，并为进一步探索更多天然药物减轻急性肾损伤的机制提供理论依据。
