Author Affiliations: Department of Community Medicine and Population Health (Dr Paxton); Life Research Institute (Dr Bui); Capstone College of Nursing (Dr Oliver); and Department of Social Work (Ms Wang), University of Alabama, Tuscaloosa; Department of Aging and Geriatric, University of Florida, Gainesville (Dr Fullwood); DCH Manderson Cancer Center (Ms Daniel and Dr Dubay); and Medical College of Wisconsin (Dr Stolley), Milwaukee.
Cancer Nurs. 2022;45(1):E246-E254. doi: 10.1097/NCC.0000000000000908.
Few studies have examined the real-time and dynamic relationship between lifestyle behaviors and treatment-related symptoms.
The aim of this study was to examine the associations of daily physical activity and sedentary behavior with symptom burden, pain interference, and fatigue among patients who were undergoing active cancer treatment.
A total of 22 (mean age = 57 years; 73% women; 55% Black) cancer patients were recruited from a local hospital and reported a daily diary of physical activity, sedentary behavior, symptom burden, pain interference, and fatigue over 10 days. Adjusted mixed-effects models were used to examine all associations.
Body mass index moderated the relationship between physical activity and symptom burden (γ = 0.06, P < .01) and physical activity and fatigue (γ = 0.09, P < .05). On days where physical activity was higher than average, symptom burden and fatigue scores were lower among patients who had lower body mass index values. Also, age moderated the relationship between sedentary behavior and symptom burden (γ = -0.04, P < .05); on days where patients sat more, symptom burden was lower among patients who were younger than the average age.
Overall, these data indicate that treatment-related symptoms vary daily within cancer patients and that physical activity may alleviate treatment-related symptoms for leaner patients. Larger samples and objective assessments of physical activity and sedentary behavior are needed to validate our results.
Oncology nurses may be in the best position to promote physical activity during treatment as a strategy to manage symptom burden.
鲜有研究探讨生活方式行为与治疗相关症状之间的实时动态关系。
本研究旨在探讨癌症患者接受积极治疗期间，日常体力活动和久坐行为与症状负担、疼痛干扰和疲劳之间的关联。
共招募了 22 名（平均年龄=57 岁；73%为女性；55%为黑人）癌症患者，他们从当地医院招募，并在 10 天内报告了日常体力活动、久坐行为、症状负担、疼痛干扰和疲劳的日记。采用调整后的混合效应模型来检验所有关联。
体重指数（BMI）调节了体力活动与症状负担（γ=0.06，P<.01）和体力活动与疲劳（γ=0.09，P<.05）之间的关系。在体力活动高于平均水平的日子里，BMI 值较低的患者症状负担和疲劳评分较低。此外，年龄调节了久坐行为与症状负担之间的关系（γ=-0.04，P<.05）；在患者久坐时间较多的日子里，年龄小于平均年龄的患者症状负担较低。
总体而言，这些数据表明癌症患者的治疗相关症状每天都在变化，体力活动可能会减轻较瘦患者的治疗相关症状。需要更大的样本量和对体力活动和久坐行为的客观评估来验证我们的结果。
肿瘤护士可能最适合在治疗期间促进体力活动，作为管理症状负担的策略。
