Institut Charles Gerhardt Montpellier, UMR 5253, CNRS-UM-ENSCM, Université de Montpellier, Place Eugène Bataillon 34095, Montpellier cedex 05, France.
J Mater Chem B. 2020 Dec 28;8(48):10878-10896. doi: 10.1039/d0tb02221g. Epub 2020 Nov 6.
The world of biomedical research is in constant evolution, requiring more and more conditions and norms through pre-clinic and clinic studies. Nanodiamonds (NDs) with exceptional optical, thermal and mechanical properties emerged on the global scientific scene and recently gained more attention in biomedicine and bioanalysis fields. Many problematics have been deliberated to better understand their in vitro and in vivo efficiency and compatibility. Light was shed on their synthesis, modification and purification steps, as well as particle size and surface properties in order to find the most suitable operating conditions. In this review, we present the latest advances of NDs use in bioapplications. A large variety of subjects including anticancer and antimicrobial systems, wound healing and tissue engineering management tools, but also bioimaging and labeling probes are tackled. The key information resulting from these recent works were evidenced to make an overview of the potential features of NDs, with a special look on emerging therapeutic and diagnosis combinations.
生物医学研究领域在不断发展，临床前和临床研究需要越来越多的条件和规范。具有出色光学、热学和力学性能的纳米金刚石（NDs）在全球科学界崭露头角，最近在生物医学和生物分析领域受到了更多关注。人们对其在体外和体内的效率和相容性进行了许多讨论。人们对其合成、修饰和纯化步骤，以及粒径和表面性质进行了研究，以找到最合适的操作条件。在这篇综述中，我们介绍了 NDs 在生物应用中的最新进展。涉及的主题多种多样，包括抗癌和抗菌系统、伤口愈合和组织工程管理工具，还有生物成像和标记探针。这些最新研究工作的关键信息证明了 NDs 的潜在特性，特别关注新兴的治疗和诊断组合。
