中药联合化疗对非小细胞肺癌患者免疫功能和生活质量的影响：一项系统评价与Meta分析方案
The effects of traditional Chinese medicine combined with chemotherapy on immune function and quality of life in patients with non-small cell lung cancer: A protocol for systematic review and meta-analysis.
作者信息
Zhao Li-Na, Yang Yin-Qing, Wang Wen-Wen, Li Qian, Xiao Hua
机构信息
School of Health Preservation and Rehabilitation.
School of Management, Chengdu University of Traditional Chinese Medicine, Sichuan, China.
出版信息
Medicine (Baltimore). 2020 Nov 6;99(45):e22859. doi: 10.1097/MD.0000000000022859.
BACKGROUND
This article will evaluate the effects of traditional Chinese medicine (TCM) combined with chemotherapy on the immune function and quality of life of patients with non-small cell lung cancer (NSCLC), and evaluate the published side effects.
METHODS
The systematic review and meta-analysis will be conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The databases we will search include: PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure, China Biomedicine, Wan fang Data, and Technology Periodical Database. The search date is from inception to June 30, 2020. There are no restrictions on the document language. The literatures included in this study are randomized controlled trials. The main results include ratio of CD3, CD4, CD8, CD4/CD8, NK cells, the level of IgA, IgG, IgM, and Karnofsky performance status score. The secondary result is to evaluate various side effects during treatment. We will use the Cochrane Collaboration tool to evaluate each study and use Review Manager software (RevMan, version 5.3) to merge and analyze the data. The 2 researchers will independently cross-screen the literature, extract data, and evaluate the quality. If there are differences, we will resolve them through discussion or consultation with a third reviewer.
RESULTS
The results of this study will provide high-quality evidence for the effect of TCM combined with chemotherapy on the immune function and quality of life of patients with NSCLC.
CONCLUSION
This article will comprehensively evaluate the effects of TCM combined with chemotherapy on the immune function and quality of life of patients with NSCLC, and provide evidence-based evidence for clinical practice.
ETHICS
Since the data used in this study is based on previous trials and does not involve patient privacy, ethical approval is not required.
STUDY REGISTRATION NUMBER
INPLASY202070071.
背景
本文将评估中药联合化疗对非小细胞肺癌（NSCLC）患者免疫功能和生活质量的影响，并评估已发表的副作用。
方法
将按照系统评价和Meta分析的首选报告项目指南进行系统评价和Meta分析。我们将检索的数据库包括：PubMed、EMBASE、Cochrane图书馆、科学网、中国知网、中国生物医学数据库、万方数据和维普期刊数据库。检索日期从建库至2020年6月30日。文献语言无限制。本研究纳入的文献为随机对照试验。主要结果包括CD3、CD4、CD8、CD4/CD8、NK细胞的比例，IgA、IgG、IgM水平以及卡诺夫斯基功能状态评分。次要结果是评估治疗期间的各种副作用。我们将使用Cochrane协作工具评估每项研究，并使用Review Manager软件（RevMan，版本5.3）合并和分析数据。两位研究人员将独立交叉筛选文献、提取数据并评估质量。如有分歧，我们将通过讨论或咨询第三位审阅者来解决。
结果
本研究结果将为中药联合化疗对NSCLC患者免疫功能和生活质量的影响提供高质量证据。
结论
本文将全面评估中药联合化疗对NSCLC患者免疫功能和生活质量的影响，并为临床实践提供循证依据。
伦理
由于本研究使用的数据基于既往试验且不涉及患者隐私，无需伦理批准。
研究注册号
INPLASY202070071。
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