Division of Life Sciences and Medicine, Cancer Research Center, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
International Cooperation Laboratory on Signal Transduction, Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer, Shanghai Key Laboratory of Hepato-Biliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Front Immunol. 2021 Mar 8;12:625472. doi: 10.3389/fimmu.2021.625472. eCollection 2021.
Neutrophils are the largest population of circulating leukocytes and the first responder against invading pathogens or other danger signals. Sophisticated machineries help them play critical roles in immunity and inflammation, including phagocytosis, superoxide production, cytokine and chemokine production, degranulation, and formation of neutrophil extracellular traps (NETs). After maturation and release from the bone marrow, neutrophils migrate to inflamed tissues in response to many stimuli. Increasing evidences indicate that neutrophils are critically involved in the pathogenesis of liver diseases, including liver cancer, thus making them promising target for the treatment of liver diseases. Here, we would like to provide the latest finding about the role of neutrophils in liver diseases and discuss the potentiality of neutrophils as target for liver diseases.
中性粒细胞是循环白细胞中数量最多的群体，也是抵御入侵病原体或其他危险信号的第一道防线。复杂的机制使它们在免疫和炎症中发挥关键作用，包括吞噬作用、超氧化物产生、细胞因子和趋化因子产生、脱粒和中性粒细胞胞外陷阱（NETs）的形成。中性粒细胞在骨髓中成熟并释放后，会响应多种刺激迁移到炎症组织中。越来越多的证据表明，中性粒细胞在肝脏疾病（包括肝癌）的发病机制中起着至关重要的作用，因此使它们成为治疗肝脏疾病的有前途的靶点。在这里，我们将提供关于中性粒细胞在肝脏疾病中的作用的最新发现，并讨论将中性粒细胞作为肝脏疾病靶点的潜力。
