Department of Basic Sciences, The American University of Antigua-College of Medicine, Coolidge, Antigua and Barbuda.
The Center of research and evaluation, The American University of Antigua-College of Medicine, Coolidge, Antigua and Barbuda.
Adv Exp Med Biol. 2021;1312:107-129. doi: 10.1007/5584_2020_595.
The biomedical applications of mesenchymal stem cells (MSCs) have gained expanding attention over the past three decades. MSCs are easily obtained from various tissue types (e.g. bone marrow, fat, cord blood, etc.), are capable of self-renewal, and could be induced to differentiate into several cell lineages for countless biomedical applications. In addition, when transplanted, MSCs are not detected by immune surveillance, thus do not lead to graft rejection. Moreover, they can home towards affected tissues and induce their therapeutic effect in a cell-base and/or a cell-free manner. These properties, and many others, have made MSCs appealing therapeutic cell candidates (for cell and/or gene therapy) in myriad clinical conditions. However, similar to any other therapeutic tool, MSCs still have their own limitations and grey areas that entail more research for better understanding and optimization. Herein, we present a brief overview of various pre-clinical/clinical applications of MSCs in regenerative medicine and discuss limitations and future challenges.
间充质干细胞（MSCs）在过去三十年中的生物医学应用受到了越来越多的关注。MSCs 易于从各种组织类型（例如骨髓、脂肪、脐带血等）中获得，具有自我更新能力，并可被诱导分化为多种细胞谱系，用于无数的生物医学应用。此外，当移植时，MSCs 不会被免疫监视检测到，因此不会导致移植物排斥。此外，它们可以向受影响的组织归巢，并以细胞基础和/或无细胞方式诱导其治疗效果。这些特性以及许多其他特性，使 MSCs 成为治疗细胞候选物（用于细胞和/或基因治疗），适用于多种临床情况。然而，与任何其他治疗工具一样，MSCs 仍然存在自身的局限性和灰色地带，需要更多的研究来更好地理解和优化。在此，我们简要概述了 MSCs 在再生医学中的各种临床前/临床应用，并讨论了其局限性和未来挑战。
