Nagata Michelle, Tome Anne, White Kami, Wilkens Lynne R, Park Song-Yi, Le Marchand Loïc, Haiman Christopher, Hernandez Brenda Y
Population Sciences in the Pacific Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA.
Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, 1975 Zonal Ave., Los Angeles, CA 90033, USA.
Cancers (Basel). 2023 Oct 28;15(21):5194. doi: 10.3390/cancers15215194.
The potential involvement of a sexually transmitted agent has been suggested to contribute to the high number of prostate cancers in the United States and worldwide. We investigated the relationship of seropositivity with prostate cancer risk in a nested case-control study within the Multiethnic Cohort in Hawaii and California using blood samples collected prior to cancer diagnoses. Incident cases of advanced prostate cancer (intermediate- to high-grade based on Gleason score ≥ 7 and/or disease spread outside the prostate) were matched to controls by age, ethnicity, and the date of blood collection. serostatus was measured using an ELISA detecting IgG antibodies against a recombinant α-actinin protein. Seropositivity to was observed in 35 of 470 (7.4%) cases and 26 of 470 (5.5%) controls (unadjusted OR = 1.47, 95% CI 0.82-2.64; adjusted OR = 1.31, 95% CI 0.67-2.53). The association was similarly not significant when cases were confined to extraprostatic tumors having regional or distant spread ( = 121) regardless of grade (unadjusted OR = 1.37, 95% CI 0.63-3.01; adjusted OR = 1.20, 95% CI 0.46-3.11). The association of with prostate cancer risk did not vary by aspirin use. Our findings do not support a role for in the etiology of advanced prostate cancer.
性传播病原体的潜在参与被认为是美国和全球前列腺癌高发的原因之一。我们在夏威夷和加利福尼亚的多民族队列中的一项巢式病例对照研究中，利用癌症诊断前采集的血样，调查了血清阳性与前列腺癌风险之间的关系。晚期前列腺癌（基于Gleason评分≥7和/或前列腺外疾病扩散，为中至高级别）的新发病例按年龄、种族和采血日期与对照进行匹配。使用检测针对重组α-肌动蛋白蛋白的IgG抗体的ELISA法测定血清状态。在470例病例中的35例（7.4%）和470例对照中的26例（5.5%）观察到血清阳性（未调整的OR = 1.47，95% CI 0.82 - 2.64；调整后的OR = 1.31，95% CI 0.67 - 2.53）。当病例局限于有区域或远处扩散的前列腺外肿瘤（n = 121）时，无论分级如何，该关联同样不显著（未调整的OR = 1.37，95% CI 0.63 - 3.01；调整后的OR = 1.20，95% CI 0.46 - 3.11）。[病原体名称]与前列腺癌风险的关联不因阿司匹林使用情况而有所不同。我们的研究结果不支持[病原体名称]在晚期前列腺癌病因学中的作用。
