Kim Jung-Hyun, Moon Hong-Sang, Kim Kyu-Shik, Hwang Hwan-Sik, Ryu Jae-Sook, Park Sung-Yul
Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, Seoul 04763, Korea.
Department of Urology, Hanyang University College of Medicine, Seoul 04763, Korea.
Korean J Parasitol. 2019 Feb;57(1):21-25. doi: 10.3347/kjp.2019.57.1.21. Epub 2019 Feb 26.
Trichomoniasis is the most common curable sexually-transmitted infection. Most Trichomonas vaginalis-infected men are asymptomatic and can remain undiagnosed and untreated, and this has been thought to result in chronic persistent prostatic infection. Chronic inflammation is regarded as the major factor in the pathogenesis and progression of benign prostatic hyperplasia (BPH) and prostatic cancer (PCa). The aim of this study is to identify seropositivity to T. vaginalis in men with prostate tumors (BPH or PCa) visited to Hanyang University Hospital. A total of 183 men were enrolled between October 2013 and November 2014. They consisted of 139 with BPH (mean age: 64.0 ± 0.07) and 44 with prostate cancer (mean age: 73.3±0.18). We carried out ELISA to identify the seropositivity to T. vaginalis. Mixed lysate antigen extracted from 8 strains of T. vaginalis was used in the ELISA. Also 58 male outpatients visited to Health Promotion Center in Hanyang University Hospital were evaluated for comparing group. As a results, seropositivity to T. vaginalis in patients with prostatic diseases was 19.7% (BPH: 18.7%, PCa: 22.7%) and it was significantly higher than the 1.7% of the comparing healthy group (P = 0.001). Therefore, prostatic tumor showed higher seropositivity against T. vaginalis than normal men. As far as we know, this is the first report about seroprevalence in prostatic tumor in Korea.
滴虫病是最常见的可治愈性传播感染。大多数感染阴道毛滴虫的男性没有症状，可能未被诊断和治疗，人们认为这会导致慢性持续性前列腺感染。慢性炎症被视为良性前列腺增生（BPH）和前列腺癌（PCa）发病机制及进展的主要因素。本研究的目的是确定在汉阳大学医院就诊的患有前列腺肿瘤（BPH或PCa）的男性中阴道毛滴虫的血清阳性率。2013年10月至2014年11月期间共招募了183名男性。他们包括139名患有BPH的男性（平均年龄：64.0±0.07）和44名患有前列腺癌的男性（平均年龄：73.3±0.18）。我们进行酶联免疫吸附测定（ELISA）以确定阴道毛滴虫的血清阳性率。ELISA中使用从8株阴道毛滴虫中提取的混合裂解物抗原。此外，对58名到汉阳大学医院健康促进中心就诊的男性门诊患者进行评估作为对照组。结果，前列腺疾病患者中阴道毛滴虫的血清阳性率为19.7%（BPH：18.7%，PCa：22.7%），显著高于对照组健康组的1.7%（P = 0.001）。因此，前列腺肿瘤患者对阴道毛滴虫的血清阳性率高于正常男性。据我们所知，这是韩国关于前列腺肿瘤血清流行率的首次报告。
