Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India;
Skinmed. 2020 Oct 1;18(5):278-285. eCollection 2020.
Vitiligo in children and adolescents displays some distinct features, which may affect its clinical course, therapeutic outcome, and prognosis. We studied 579 children and adolescents with vitiligo, comprising 275 (47.5%) boys and 304 (52.5%) girls (male:female ratio [m:f], 1:1.1) aged between 2 and 19 years (mean ± SD 11.13 ± 4.23 years). The majority of children (301, 52%) were aged >5-12 years, and 221 (38.2%) were adolescents; onset of vitiligo in the above groups occurred between the ages of 2 and 19 years (mean ± SD 9.18 ± 4.08 years). The majority of patients (337, 58.2%) had developed vitiligo between 5 and 12 years of age, and 332 (57.4%) patients had a medical consultation within 1 year of the onset of the disease. The involvement of up to 10% of body surface area in 569 (98.3%) patients, generalized vitiligo in 328 (56.7%) patients, and focal vitiligo in 158 (27.3%) patients were the major presentations. Only 150 (15.9%) patients had family members affected by vitiligo, and associated systemic disorders, predominately thyroid abnormalities, occurred in three (0.5%) patients. Vitiligo was more frequent in children aged 5-12 years, and it affected girls with a slight preponderance, commonly presenting as generalized vitiligo and focal/localized vitiligo. Patients with a family history of vitiligo had an earlier onset but without a statistically significant difference. Local trauma is an important trigger, and screening for thyroid disorders appears important.
儿童和青少年白癜风具有一些独特的特征，这些特征可能会影响其临床过程、治疗效果和预后。我们研究了 579 例儿童和青少年白癜风患者，其中男 275 例（47.5%），女 304 例（52.5%）（男女比例 [m:f]，1:1.1），年龄在 2 至 19 岁之间（平均±标准差 11.13±4.23 岁）。大多数儿童（301 例，52%）年龄>5-12 岁，221 例（38.2%）为青少年；上述两组白癜风发病年龄为 2 至 19 岁（平均±标准差 9.18±4.08 岁）。大多数患者（337 例，58.2%）发病年龄在 5-12 岁之间，332 例（57.4%）患者在发病后 1 年内就诊。569 例（98.3%）患者受累体表面积达 10%以下，328 例（56.7%）患者为泛发性白癜风，158 例（27.3%）患者为局限性/局灶性白癜风。仅 150 例（15.9%）患者有家族成员患有白癜风，3 例（0.5%）患者伴有甲状腺异常等系统性疾病。5-12 岁儿童白癜风发病率较高，以女孩多见，多表现为泛发性白癜风和局限性/局灶性白癜风。有家族史的患者发病较早，但无统计学差异。局部创伤是一个重要的诱发因素，筛查甲状腺疾病似乎很重要。
