Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Bioorg Chem. 2020 Dec;105:104429. doi: 10.1016/j.bioorg.2020.104429. Epub 2020 Oct 28.
Human serum albumin (HSA) as the most abundant protein in human blood plasma, can be a good indicator for evaluating severity of some diseases in the clinic. HSA can be find in two forms: reduced albumin (human mercaptalbumin (HMA)) and oxidized albumin (human non-mercaptalbumin (HNA)). The rate of oxidized albumin to total albumin can be enhanced in multiple diseases. Increase in HNA level have been demonstrated in liver, diabetes plus fatigue and coronary artery diseases. In liver patients, this enhancement can reach to 50-200 percent which can then lead to bacterial/viral infections and eventually death in severe conditions. Due to the induction of cytokine storm, we can say that the level of HNA in serum of coronavirus disease 2019 (COVID-19) patients may be a positive predictor of mortality, especially in patients with underlying diseases such as cardiovascular disease (CVD), diabetes, aging and other inflammatory diseases. We suggest that checking oxidized albumin in COVID-19 patients may provide new therapeutic and diagnostic opportunities to better combat COVID-19.
人血清白蛋白（HSA）作为人类血浆中最丰富的蛋白质，可以作为临床评估某些疾病严重程度的良好指标。HSA 有两种形式：还原白蛋白（人巯基白蛋白（HMA））和氧化白蛋白（人非巯基白蛋白（HNA））。在多种疾病中，氧化白蛋白与总白蛋白的比率会增加。HNA 水平的增加已在肝脏、糖尿病加疲劳和冠状动脉疾病中得到证实。在肝脏患者中，这种增加可以达到 50-200%，这可能导致细菌/病毒感染，在严重情况下最终导致死亡。由于细胞因子风暴的诱导，我们可以说 2019 年冠状病毒病（COVID-19）患者血清中 HNA 的水平可能是死亡率的一个阳性预测因子，特别是在患有心血管疾病（CVD）、糖尿病、衰老和其他炎症性疾病等潜在疾病的患者中。我们建议检查 COVID-19 患者的氧化白蛋白可能为更好地对抗 COVID-19 提供新的治疗和诊断机会。
