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人类c-Ha-ras1基因3'端的一个重复序列元件具有增强子活性。

A repetitive sequence element 3' of the human c-Ha-ras1 gene has enhancer activity.

作者信息

Cohen J B, Walter M V, Levinson A D

机构信息

Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080.

出版信息

J Cell Physiol Suppl. 1987;Suppl 5:75-81. doi: 10.1002/jcp.1041330415.

DOI:10.1002/jcp.1041330415
PMID:3316256
Abstract

Efficient expression of the human c-Ha-ras1 gene requires sequences 3' of those specifying the polyadenylation of its transcripts. These sequences can stimulate the expression of heterologous genes in a manner largely independent of position and orientation, arguing that they possess a transcriptional enhancing activity that regulates the c-Ha-ras1 promoter. As this element is associated with a repetitive domain that is highly polymorphic, it is possible that the activity of this enhancer is variable within the human population.

摘要

人类c-Ha-ras1基因的有效表达需要位于其转录本聚腺苷酸化位点下游的序列。这些序列能够以一种在很大程度上独立于位置和方向的方式刺激异源基因的表达，这表明它们具有调节c-Ha-ras1启动子的转录增强活性。由于该元件与一个高度多态的重复结构域相关联，因此这种增强子的活性在人群中可能存在差异。

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