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具有免疫力丧失的COVID-19大流行的SIRSi compartmental模型。

SIRSi compartmental model for COVID-19 pandemic with immunity loss.

作者信息

Batistela Cristiane M, Correa Diego P F, Bueno Átila M, Piqueira José Roberto C

机构信息

Polytechnic School of University of São Paulo - EPUSP, São Paulo, SP, Brazil.

Federal University of ABC - UFABC, São Bernardo do Campo, SP, Brazil.

出版信息

Chaos Solitons Fractals. 2021 Jan;142:110388. doi: 10.1016/j.chaos.2020.110388. Epub 2020 Oct 29.

Abstract

The coronavirus disease 2019 (Covid-19) outbreak led the world to an unprecedented health and economic crisis. In an attempt to respond to this emergency, researchers worldwide are intensively studying the dynamics of the Covid-19 pandemic. In this study, a Susceptible - Infected - Removed - Sick (SIRSi) compartmental model is proposed, which is a modification of the classical Susceptible - Infected - Removed (SIR) model. The proposed model considers the possibility of unreported or asymptomatic cases, and differences in the immunity within a population, i.e., the possibility that the acquired immunity may be temporary, which occurs when adopting one of the parameters ( ) other than zero. Local asymptotic stability and endemic equilibrium conditions are proved for the proposed model. The model is adjusted to the data from three major cities of the state of São Paulo in Brazil, namely, São Paulo, Santos, and Campinas, providing estimations of duration and peaks related to the disease propagation. This study reveals that temporary immunity favors a second wave of infection and it depends on the time interval for a recovered person to be susceptible again. It also indicates the possibility that a greater number of patients would get infected with decreased time for reinfection.

摘要

2019年冠状病毒病(Covid-19)疫情给世界带来了前所未有的健康和经济危机。为应对这一紧急情况,全球研究人员正在深入研究Covid-19大流行的动态。在本研究中,提出了一种易感-感染-移除-患病(SIRSi) compartmental模型,它是经典易感-感染-移除(SIR)模型的一种改进。所提出的模型考虑了未报告或无症状病例的可能性,以及人群中免疫力的差异,即获得性免疫可能是暂时的这种可能性,当采用非零的参数( )之一时就会出现这种情况。证明了所提出模型的局部渐近稳定性和地方病平衡条件。该模型根据巴西圣保罗州三个主要城市,即圣保罗、桑托斯和坎皮纳斯的数据进行了调整,提供了与疾病传播相关的持续时间和峰值的估计。本研究表明,暂时免疫有利于第二波感染,并且这取决于康复者再次易感的时间间隔。它还表明了随着再感染时间减少会有更多患者被感染的可能性。

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