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细胞因子风暴诱发新型冠状病毒肺炎患者新发抑郁症。对抑郁症与细胞因子之间关联的新审视——两例病例报告。

Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports.

作者信息

Alpert Orna, Begun Leonid, Garren Patrik, Solhkhah Ramon

机构信息

Department of Psychiatry & Behavioral Health, Jersey Shore University Medical Center and Hackensack Meridian School of Medicine at Seton Hall University, United States.

Department of Psychiatry, Jersey Shore University Hospital, United States.

出版信息

Brain Behav Immun Health. 2020 Dec;9:100173. doi: 10.1016/j.bbih.2020.100173. Epub 2020 Nov 3.

DOI:10.1016/j.bbih.2020.100173
PMID:33163979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7606074/
Abstract

BACKGROUND: Depression appears to be a common complication in patients during and post-COVID-19 infection. Understanding the mechanism of action of cytokines such as interleukin-6, interleukin-10 and others in depression and in cytokine storm syndrome, the core component of COVID- 19, could shine a new light on future treatment options for both disorders. OBJECTIVE: This review demonstrates the role of interleukins in COVID-19 pathogenesis and their role in depression. RESULTS: We described cases we have treated as an example for the dual role interleukins have in COVID-19 infection and depression and reviewed approximately 70 articles focusing on the role of interleukins in cytokine storm syndrome and depression. CONCLUSION: This review highlights the key features of cytokines in both diseases. As the scientific community has more time to recover and process the effect of the current pandemic, we believe that additional research will pave the way to diverse pathways to treat depression in these patient and others.

摘要

背景：抑郁症似乎是新冠病毒感染期间及感染后的常见并发症。了解白细胞介素-6、白细胞介素-10等细胞因子在抑郁症以及细胞因子风暴综合征（新冠病毒的核心组成部分）中的作用机制，可能为这两种疾病的未来治疗方案带来新的启示。 目的：本综述阐述白细胞介素在新冠病毒发病机制中的作用及其在抑郁症中的作用。 结果：我们以所治疗的病例为例，说明白细胞介素在新冠病毒感染和抑郁症中的双重作用，并回顾了约70篇关注白细胞介素在细胞因子风暴综合征和抑郁症中作用的文章。 结论：本综述突出了细胞因子在这两种疾病中的关键特征。随着科学界有更多时间恢复并研究当前大流行的影响，我们相信更多研究将为治疗这些患者及其他患者的抑郁症开辟多种途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b120/8474377/9bf8e6ea67a1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b120/8474377/9bf8e6ea67a1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b120/8474377/9bf8e6ea67a1/gr1.jpg

相似文献

[1]
Cytokine storm induced new onset depression in patients with COVID-19. A new look into the association between depression and cytokines -two case reports.

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Post-COVID-19 Syndrome as Described by Patients: A Qualitative Study.

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[2]
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[3]
Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives.

Mol Neurobiol. 2024-12

[4]
Long COVID-19 Pathophysiology: What Do We Know So Far?

Microorganisms. 2023-9-30

[5]
Post-COVID Interstitial Lung Disease and Other Lung Sequelae.

Clin Chest Med. 2023-6

[6]
Psychiatry in the time of the pandemic. Is COVID-19 changing the discipline?

Postep Psychiatr Neurol. 2021-6

[7]
Correction of Psychoemotional Disorders and Short-Term Prognosis in Patients with COVID-19.

Neurosci Behav Physiol. 2022

[8]
Long COVID: a narrative review of the clinical aftermaths of COVID-19 with a focus on the putative pathophysiology and aspects of physical activity.

Oxf Open Immunol. 2022-9-16

[9]
Depression, Anxiety, and Quality of Life in Patients Treated with Single Infusion Tocilizumab for COVID-19: A Follow-up, Controlled Study.

Indian J Psychol Med. 2023-1

[10]
Impact of Rehabilitation on Physical and Neuropsychological Health of Patients Who Acquired COVID-19 in the Workplace.

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本文引用的文献

[1]
Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study.

JAMA Psychiatry. 2021-2-1

[2]
Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study.

Brain Behav Immun. 2020-5-19

[3]
Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients.

EBioMedicine. 2020-4-18

[4]
Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study.

Lancet Infect Dis. 2020-4-27

[5]
Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases.

Respir Med Case Rep. 2020-4-21

[6]
Cytokine release syndrome in severe COVID-19.

Science. 2020-5-1

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Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms.

Brain Behav Immun. 2020-4-13

[8]
Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

J Autoimmun. 2020-4-10

[9]
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.

JAMA Neurol. 2020-6-1

[10]
Role of Interleukin-6 in Depressive Disorder.

Int J Mol Sci. 2020-3-22

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