Alpert Orna, Begun Leonid, Garren Patrik, Solhkhah Ramon
Department of Psychiatry & Behavioral Health, Jersey Shore University Medical Center and Hackensack Meridian School of Medicine at Seton Hall University, United States.
Department of Psychiatry, Jersey Shore University Hospital, United States.
Brain Behav Immun Health. 2020 Dec;9:100173. doi: 10.1016/j.bbih.2020.100173. Epub 2020 Nov 3.
Depression appears to be a common complication in patients during and post-COVID-19 infection. Understanding the mechanism of action of cytokines such as interleukin-6, interleukin-10 and others in depression and in cytokine storm syndrome, the core component of COVID- 19, could shine a new light on future treatment options for both disorders.
This review demonstrates the role of interleukins in COVID-19 pathogenesis and their role in depression.
We described cases we have treated as an example for the dual role interleukins have in COVID-19 infection and depression and reviewed approximately 70 articles focusing on the role of interleukins in cytokine storm syndrome and depression.
This review highlights the key features of cytokines in both diseases. As the scientific community has more time to recover and process the effect of the current pandemic, we believe that additional research will pave the way to diverse pathways to treat depression in these patient and others.
抑郁症似乎是新冠病毒感染期间及感染后的常见并发症。了解白细胞介素-6、白细胞介素-10等细胞因子在抑郁症以及细胞因子风暴综合征（新冠病毒的核心组成部分）中的作用机制，可能为这两种疾病的未来治疗方案带来新的启示。
本综述阐述白细胞介素在新冠病毒发病机制中的作用及其在抑郁症中的作用。
我们以所治疗的病例为例，说明白细胞介素在新冠病毒感染和抑郁症中的双重作用，并回顾了约70篇关注白细胞介素在细胞因子风暴综合征和抑郁症中作用的文章。
本综述突出了细胞因子在这两种疾病中的关键特征。随着科学界有更多时间恢复并研究当前大流行的影响，我们相信更多研究将为治疗这些患者及其他患者的抑郁症开辟多种途径。
