Saad Mabroka H, El-Fakharany Esmail M, Salem Marwa S, Sidkey Nagwa M
Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technology Applications (SRTA-City), New Borg EL Arab, Alexandria, Egypt.
Botany & Microbiology Department, Faculty of Science, Al Azhar University (Girls Branch), Nasr City, Egypt.
J Biomol Struct Dyn. 2022 Apr;40(6):2828-2850. doi: 10.1080/07391102.2020.1838948. Epub 2020 Nov 8.
Cyanobacteria are photosynthetic, Gram-negative bacteria that are considered one of the most morphologically diverse groups of prokaryotes with a chief role in the global nutrient cycle as they fixed gaseous carbon dioxide and nitrogen to organic materials. Cyanobacteria have significant adaptability to survive in harsh conditions due to they have different metabolic pathways with unique compounds, effective defensive mechanisms, and wide distribution in different habitats. Besides, they are successfully used to face different challenges in several fields, including industry, aquaculture, agriculture, food, dairy products, pollution control, bioenergy, and pharmaceutics. Analysis of 680 publications revealed that nearly 1630 cyanobacterial molecules belong to different families have a wide range of applications in several fields, including cosmetology, agriculture, pharmacology (immunosuppressant, anticancer, antibacterial, antiprotozoal, antifungal, anti-inflammatory, antimalarial, anticoagulant, anti-tuberculosis, antitumor, and antiviral activities) and food industry. In this review, we nearly mentioned 92 examples of cyanobacterial molecules that are considered the most relevant effects related to anti-inflammatory, antioxidant, antimicrobial, antiviral, and anticancer activities as well as their roles that can be used in various biotechnological fields. These cyanobacterial products might be promising candidates for fighting various diseases and can be used in managing viral and microbial infections.Communicated by Ramaswamy H. Sarma.
蓝细菌是光合革兰氏阴性细菌，被认为是原核生物中形态最多样化的群体之一，在全球营养循环中起着主要作用，因为它们能将气态二氧化碳和氮固定为有机物质。蓝细菌具有很强的适应能力，能够在恶劣条件下生存，这是由于它们具有不同的代谢途径、独特的化合物、有效的防御机制，并且广泛分布于不同的栖息地。此外，它们已成功应用于多个领域，包括工业、水产养殖、农业、食品、乳制品、污染控制、生物能源和制药等，以应对不同的挑战。对680篇出版物的分析表明，近1630种属于不同家族的蓝细菌分子在多个领域有广泛应用，包括美容、农业、药理学（免疫抑制、抗癌、抗菌、抗原生动物、抗真菌、抗炎、抗疟疾、抗凝、抗结核、抗肿瘤和抗病毒活性）以及食品工业。在本综述中，我们几乎提及了92个蓝细菌分子的例子，这些分子被认为与抗炎、抗氧化、抗菌、抗病毒和抗癌活性以及它们在各种生物技术领域中的作用最为相关。这些蓝细菌产物可能是对抗各种疾病的有前途的候选物，可用于控制病毒和微生物感染。由拉马斯瓦米·H·萨尔马传达。
