Moura João Daniel Mendonça de, Rodrigues Patricia de Almeida, Dos Santos Vinicius Ruan Neves, Bittencourt Leonardo Oliveira, Matos-Sousa José Mario, Peinado Beatriz Rodrgiues Risuenho, Perdigão José Messias, Rogez Herve, Collares Fabrício Mezzomo, Lima Rafael Rodrigues
Department of Dentistry, School of Dentistry, Federal University of Pará, Belém, Pará, Brazil.
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.
Heliyon. 2024 May 10;10(10):e31067. doi: 10.1016/j.heliyon.2024.e31067. eCollection 2024 May 30.
The açai juice contains high concentrations of phenolic compounds, including cyanidin-3-glucoside and others flavonoids. The aim of this study was to evaluate the impact of açai supplementation on healthy mandibular alveolar bone in male albino rats of the Wistar strain. 24 rats were divided into 3 groups, in which one group received a daily dose of saline solution and the other two groups were treated with daily doses of clarified açai juice for 14 or 28 days. After the experiment, hemimandibles were collected and analyzed using Scanning Electron Microscopy (SEM), histological assessments, and micro-CT. Results showed changes in the integrity of the alveolar bone as seen in SEM, increased osteocyte density and higher collagen matrix area in the açai group compared to the control group as seen in histological analysis, and increased bone volume, trabecular thickness and number, and cortical bone as seen in micro-CT analysis. The space between bone trabeculae showed no difference among the groups. These results suggest that açai supplementation may have a structural change effect on alveolar bone, but further research is needed to confirm these findings in humans and to determine the exact mechanisms behind these effects.
阿萨伊果汁含有高浓度的酚类化合物，包括矢车菊素-3-葡萄糖苷和其他类黄酮。本研究的目的是评估补充阿萨伊对Wistar品系雄性白化大鼠健康下颌牙槽骨的影响。将24只大鼠分为3组，其中一组每日给予盐溶液，另外两组分别每日给予澄清的阿萨伊果汁，持续14天或28天。实验结束后，收集半侧下颌骨，使用扫描电子显微镜（SEM）、组织学评估和微型计算机断层扫描（micro-CT）进行分析。结果显示，SEM观察到牙槽骨完整性发生变化；组织学分析显示，与对照组相比，阿萨伊组骨细胞密度增加，胶原基质面积增大；micro-CT分析显示，骨体积、骨小梁厚度和数量以及皮质骨均增加。各组骨小梁之间的间隙无差异。这些结果表明，补充阿萨伊可能对牙槽骨有结构改变作用，但需要进一步研究以在人体中证实这些发现，并确定这些作用背后的确切机制。
