Institut National d'Hygiène (INH), Lomé, Togo.
Département de Santé Publique, Université de Lomé, Lomé, Togo.
PLoS One. 2020 Nov 9;15(11):e0242124. doi: 10.1371/journal.pone.0242124. eCollection 2020.
In December 2019, the COVID-19 outbreak began in China and quickly spread throughout the world and was reclassified as a pandemic in March 2020. The first case of COVID-19 was declared in Togo on March 5. Two months later, few data were available to describe the circulation of the new coronavirus in the country.
This survey aimed to estimate the prevalence of SARS-CoV-2 in high-risk populations in Lomé.
From April 23, 2020, to May 8, 2020, we recruited a sample of participants from five sectors: health care, air transport, police, road transport and informal. We collected oropharyngeal swabs for direct detection through real-time reverse transcription polymerase chain reaction (rRT-PCR) and blood for antibody detection by serological tests. The overall prevalence (current and past) of infection was defined by positivity for both tests.
A total of 955 participants with a median age of 36 (IQR 32-43) were included, and 71.6% (n = 684) were men. Approximately 22.1% (n = 212) were from the air transport sector, 20.5% (n = 196) were from the police sector, and 38.7% (n = 370) were from the health sector. Seven participants (0.7%, 95% CI: 0.3-1.6%) had a positive rRT-PCR test result at the time of recruitment, and nine (0.9%, 95% CI: 0.4-1.8%) were seropositive for IgM or IgG against SARS-CoV-2. We found an overall prevalence of 1.6% (n = 15), 95% CI: 0.9-2.6%.
The prevalence of SARS-CoV-2 infection among high-risk populations in Lomé was relatively low and could be explained by the various measures taken by the Togolese government. Therefore, we recommend targeted screening.
2019 年 12 月，COVID-19 疫情在中国爆发，并迅速蔓延至全球，并于 2020 年 3 月被重新归类为大流行。第一例 COVID-19 病例于 3 月 5 日在多哥宣布。两个月后，几乎没有数据可用于描述该国新冠状病毒的传播情况。
本调查旨在估计洛美高危人群中 SARS-CoV-2 的流行率。
从 2020 年 4 月 23 日至 5 月 8 日，我们从五个部门（医疗保健、航空运输、警察、道路运输和非正规部门）招募了一个样本。我们采集了口咽拭子进行实时逆转录聚合酶链反应（rRT-PCR）直接检测，并采集血液进行血清学检测以检测抗体。通过两种检测均为阳性来定义当前和过去的总体感染率（感染率）。
共纳入 955 名中位年龄为 36 岁（IQR 32-43）的参与者，其中 71.6%（n=684）为男性。大约 22.1%（n=212）来自航空运输部门，20.5%（n=196）来自警察部门，38.7%（n=370）来自医疗保健部门。7 名参与者（0.7%，95%CI：0.3-1.6%）在招募时 rRT-PCR 检测结果为阳性，9 名参与者（0.9%，95%CI：0.4-1.8%）针对 SARS-CoV-2 的 IgM 或 IgG 呈血清阳性。我们发现总体感染率为 1.6%（n=15），95%CI：0.9-2.6%。
洛美高危人群中 SARS-CoV-2 感染的流行率相对较低，这可能是由于多哥政府采取的各种措施。因此，我们建议进行有针对性的筛查。
