Valenti A J, Siniscalchi A J, Andriole V T
Yale J Biol Med. 1977 Mar-Apr;50(2):177-82.
Twenty-five isolates of Staphylococcus aureus, 24 isolates of Escherichia coli, and 25 isolates of Klebsiella pneumoniae obtained from clinical material were tested in vitro for susceptibility to cefamandole, tobramycin and combinations of the two antibiotics utilizing an automated microdilution system. Synergistic or partially synergistic bactericidal effects of the combination were observed against 15 of the S. aureus isolates (60%), 23 of the E. coli isolates (96%), and 19 of the K. pneumoniae isolates (76%) tested. No antagonistic effects of the combination were noted. This study suggests that cefamandole-tobramycin combinations are capable of acting synergistically in vitro against certain gram-positive and gram-negative organisms and may have potential usefulness in clinical situations such as gram-negative rod and staphylococcal sepsis.
从临床材料中获取的25株金黄色葡萄球菌、24株大肠杆菌和25株肺炎克雷伯菌，利用自动微量稀释系统在体外检测了它们对头孢孟多、妥布霉素以及这两种抗生素组合的敏感性。在所检测的金黄色葡萄球菌分离株中，观察到组合药物对15株（60%）有协同或部分协同杀菌作用；对大肠杆菌分离株中的23株（96%）有协同或部分协同杀菌作用；对肺炎克雷伯菌分离株中的19株（76%）有协同或部分协同杀菌作用。未观察到组合药物有拮抗作用。本研究提示，头孢孟多与妥布霉素组合在体外对某些革兰氏阳性和革兰氏阴性菌有协同作用，在革兰氏阴性杆菌和葡萄球菌败血症等临床情况中可能有潜在用途。
