类黄酮补充剂增加神经营养因子活性，以调节视网膜遗传疾病的炎症。
Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases.
机构信息
MAGI EUREGIO, Bolzano, Italy.
Department of Ophthalmology, Catholic University of Sacred Heart, Gemelli Policlinic, Rome, Italy.
出版信息
Acta Biomed. 2020 Nov 9;91(13-S):e2020014. doi: 10.23750/abm.v91i13-S.10683.
Retinal degenerative disorders induce loss of photoreceptors associated with inflammation, and negative remodeling and plasticity of neural retina. Retinal degenerative diseases may have genetic and/or environmental causes. Degeneration of retinal pigment epithelium cells initiates a vicious circle increasing the ongoing inflammation in both retina and choroid. Flavonoids are polyphenolic molecules with antioxidant activity and dietary intake, specifically of anthocyanins and flavanols, improves oxidative stress and neuro-inflammation. In vitro and ex vivo studies have also revealed biological effects of flavonoids on retinal protection against oxidative stress and inflammation. In this brief review, the protective role of flavonoids against retinal degeneration and inflammation will be discussed along with their therapeutic potential for the treatment of retinal degenerative diseases.
视网膜退行性疾病可引起光感受器丧失，同时伴有炎症、神经视网膜的负性重塑和可塑性。视网膜退行性疾病可能具有遗传和/或环境原因。视网膜色素上皮细胞的退化会引发恶性循环，加剧视网膜和脉络膜的持续炎症。类黄酮是具有抗氧化活性的多酚类分子，饮食中类黄酮的摄入，特别是花色苷和黄烷醇的摄入，可以改善氧化应激和神经炎症。体外和离体研究也揭示了类黄酮对视网膜的生物保护作用，可抵抗氧化应激和炎症。在这篇简要综述中，将讨论类黄酮对视网膜变性和炎症的保护作用，以及它们在治疗视网膜退行性疾病方面的治疗潜力。
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